Results 71 to 80 of about 15,353,657 (286)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Accelerated Lane-Changing Trajectory Planning of Automated Vehicles with Vehicle-to-Vehicle Collaboration

Journal of Advanced Transportation, 2017
Considering the complexity of lane changing using automated vehicles and the frequency of turning lanes in city settings, this paper aims to generate an accelerated lane-changing trajectory using vehicle-to-vehicle collaboration (V2VC).
Haijian Bai, Jianfeng Shen, Liyang Wei, Zhongxiang Feng   +3 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Lane County food waste to energy feasibility study: final report

, 2009
"The goal of the Lane County Food Waste to Energy Feasability Study is to determine if it is financially feasible to construct and operate a Lane County owned anaerobic digestion facility to process local food waste into energy"--Page 2."Renewable Energy

core  

Prediction of the vehicle lane‐changing distance in an urban inter‐tunnel weaving section based on wavelet transform and dual‐channel neural network

IET Intelligent Transport Systems
Vehicle lane‐changing behaviour is often regarded as transient traffic behaviour while ignoring behavioural characteristics of the lane‐changing process.
Changfeng Zhu, Chun An, Runtian He, Chao Zhang, Linna Cheng   +4 more
doaj   +1 more source

A Deep Learning Method for Lane Changing Situation Assessment and Decision Making

IEEE Access, 2019
Compared with the lane keeping maneuvers, lane changing maneuvers are much more complicated. Inappropriate ones may result in traffic accidents. Therefore, it is necessary to develop vehicular social networks (VSNs) and advanced driver assistance systems
Xiao Liu, Jun Liang, Bing Xu
doaj   +1 more source

Modeling the Pedestrian Ability of Detecting Lanes and Lane Changing Behavior

Modern Applied Science, 2016
Incorporating decision-making capability as an intelligence aspect into crowd dynamics models is crucial factor for reproducing realistic pedestrian flow. Crowd dynamics models are still suffering from poor representation of essential behaviors such as lane changing behavior.
openaire   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Dynamic Multiobjective Optimization of Lane-Changing Trajectories Based on Reinforcement Learning

Journal of Advanced Transportation
To enhance the rationality of lane-changing decisions and the adaptability of trajectory planning, this study incorporates short-term driving styles to construct a multiobjective optimized lane-changing trajectory planning model based on naturalistic ...
Mengzhu Yang, Jianjun Wang, Jingtao Li
doaj   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source