Results 41 to 50 of about 3,259,215 (246)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Recurrent Cross Attention Mechanism for Improved Robustness and Real-Time Performance in Lane Detection

IEEE Access
Lane detection is a key technical challenge in autonomous driving and advanced driving assistance systems. The current lane detection system has insufficient robustness and low detection accuracy problem in complex and harsh environmental conditions, and
Bingqiang Huang, Shiqian Wang, Zhengshun Fei, Xinjian Xiang, Shaohua Tian, Fuying Tang, Tianshun Yuan   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The research on edge detection algorithm of lane

EURASIP Journal on Image and Video Processing, 2018
In developed countries, the automation and intelligent development of vehicles has reached a relatively high level and has gradually developed in China. In recent years, algorithms for lane detection have emerged in an endless stream, but the advantages ...
Zhong-xun Wang, Wenqi Wang
doaj   +1 more source

Ego Vehicle Lane Detection and Key Point Determination Using Deep Convolutional Neural Networks and Inverse Projection Mapping

Transport and Telecommunication, 2023
Ego lane detection is one of the key techniques in Ego Lane Analysis System (ELAS) implemented in smart autonomous driving cars for lane detection in roads.
Bolimera Anudeepsekhar, Muthalagu Raja, Kalaichelvi V., Singh Abhilasha   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Practical limitations of lane detection algorithm based on Hough transform in challenging scenarios

International Journal of Advanced Robotic Systems, 2021
The vision-based road lane detection technique plays a key role in driver assistance system. While existing lane recognition algorithms demonstrated over 90% detection rate, the validation test was usually conducted on limited scenarios. Significant gaps
Qiao Huang, Jinlong Liu
doaj   +1 more source

Automated Road Lane Detection for Intelligent Vehicles [PDF]

, 2012
Automated road lane detection is the crucial part of vision-based driver assistance system of intelligent vehicles. This driver assistance system reduces the road accidents, enhances safety and improves the traffic conditions.
Tauhidul Alam, Dipanjan Das Roy, Dr. Anik Saha, Kaushik Deb   +3 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source