Results 41 to 50 of about 5,323,569 (255)
Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms
Advanced Healthcare Materials, EarlyView.Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet +11 more
wiley +1 more source
Isolated Adult Langerhans' Cell Histiocytosis in Cervical Lymph Nodes: Should It Be Treated?
, 2011 Objective: We report an extremely rare case of Langerhans' cell histiocytosis involving isolated cervical lymph nodes, and we discuss the diagnosis and treatment of this infrequent disease.
羅武嘉;鄭博文 +1 more
core +1 more source
Advanced Science, EarlyView.HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan +7 more
wiley +1 more source
Histiocitosis de células de Langerhans del adulto [PDF]
, 2019 Langerhans cell histiocytosis, previously called histiocytosis X, is a disease characterized by the proliferation of CD1a dendritic cells. Its nature, reactive or neoplastic, is still discussed. Its onset in adulthood is uncommon.
Donatti, Lucila +5 more
core
Advanced Science, EarlyView.Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li +9 more
wiley +1 more source
A Case of Orbital Langerhans Cell Histiocytosis in an Adult
Acta Médica Portuguesa, 2019 Langerhans cell histiocytosis remains an enigmatic disease with a very heterogeneous presentation. We describe a rare case of orbital Langerhans cell histiocytosis in a 39-year-old female patient who presented right orbital pain and edema of the upper ...
Inês Carneiro +2 more
doaj +1 more source
Langerhans cell histiocytosis [PDF]
Blood, 2020 Abstract Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.
Carl E. Allen, Carlos Rodriguez-Galindo
openaire +2 more sources
Langerhans cell histiocytosis of the orbit
, 2013 Purpose: The management of Langerhans cell histiocytosis is controversial.
KIRATLI, HAYYAM +2 more
core +1 more source
Langerhans Cell Histiocytosis: An Unusual Presentation
Philippine Journal of Otolaryngology Head and Neck Surgery, 2008 Objective: To describe an unusual presentation of Langerhans cell histiocytosis in the craniofacial skeleton in a patient previously diagnosed with Pott’s disease. Methods: Design: Case report. Setting: Tertiary care center. Patient: One
Kathleen R. Fellizar +1 more
doaj +1 more source
Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart
Arthritis &Rheumatology, EarlyView.Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald +9 more
wiley +1 more source