Parallel evolution across replicate populations has provided evolutionary biologists with iconic examples of adaptation. When multiple populations colonize seemingly similar habitats, they may evolve similar genes, traits, or functions.
Barrett, Rowan DH +4 more
core
Immunohistochemical study of Langerhans cells in periapical lesions : correlation with inflammatory cell infiltration and epithelial cell proliferation [PDF]
Aim: The aim of this study is to determine the presence and distribution of Langerhans cells in periapical lesions, and correlate this with inflammatory cell infiltration and epithelial cell proliferation.
Carrillo García, Celia +4 more
core +1 more source
Streptozotocin induced hyperglycemia in the axolotl
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen +2 more
wiley +1 more source
Gastrointestinal Tract Involvement of Langerhans Cell Histiocytosis: Concerning Point of Diagnosis
An 8-month-old girl presented with chronic mucous bloody diarrhea for 3 months. She was diagnosed as infective gastroenteritis and did not improve after antibiotic treatment.
Shevachut Chavananon +2 more
doaj +1 more source
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang +5 more
wiley +1 more source
Indeterminate cell histocytosis with naïve cells
Histiocytoses are a heterogeneous group of disorders characterized by proliferation and accumulation of cells of mononuclearmacrophage system and dendritic cells.
Sheren F Younes +3 more
doaj +1 more source
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez +59 more
core +2 more sources
Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]
open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon +9 more
core +2 more sources
Isolated gastrointestinal Langerhans cell histiocytosis in a 16‐month‐old child: A case report
Abstract Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells, most often involving the skin or bone. Isolated gastrointestinal (GI) involvement is extremely uncommon in young children. We report a 16‐month‐old girl with a 1‐month history of chronic vomiting, bloody diarrhea, and failure to ...
Al‐Qasim AL‐Bahlani +3 more
wiley +1 more source
Adult Langerhans cell histiocytosis with pulmonary and colorectoanal involvement: a case report
Background Langerhans cell histiocytosis is a rare systemic disease characterized by the abnormal overproduction of histiocytes that tend to infiltrate single or multiple organ systems leading to significant tissue damage. It mainly affects – by order of
Mohamad Jihad Mansour +4 more
doaj +1 more source

