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GAG Multivalent Systems to Interact with Langerin
Current Medicinal Chemistry, 2022: Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role protecting organisms against pathogen infections. To address this aim, Langerin presents at least two recognition sites, one Ca2+-dependent and another one independent, which are capable to recognize a variety of carbohydrate ligands.
, Pedro M Nieto, JOSÉ L DE PAZ
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Langerin functions as an antiviral receptor on Langerhans cells
Immunology and Cell Biology, 2010Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C‐type lectin Langerin.
Teunis B H Geijtenbeek +1 more
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Calcium‐Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides [PDF]
ChemBioChem, 2017 AbstractThe C‐type lectin receptor Langerin is a glycan‐binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most Langerin ligands are recognized by a canonical Ca2+‐dependent binding site, heparins have been proposed to make additional contacts to a secondary, Ca2 ...
Jonas Hanske +2 more
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Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin
Biochemistry, 2016Langerin, a C-type lectin, is expressed in Langerhans cells. It was reported that langerin binds sulfated glycans, which is an important initial step for its role in blocking human immunodeficiency virus (HIV) transmission by capturing HIV pathogens and mediating their internalization into Birbeck granules for their elimination.
Jing, Zhao +6 more
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Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin [PDF]
Immunological Reviews, 2010 Summary: Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis. By electron microscopy, their identifying feature is the unique rod‐ or tennis racket‐shaped Birbeck granule.
Nikolaus Romani +2 more
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Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model
Biochemistry, 2009Dendritic cells, a sentinel immunity cell lineage, include different cell subsets that express various C-type lectins. For example, epidermal Langerhans cells express langerin, and some dermal dendritic cells express DC-SIGN. Langerin is a crucial component of Birbeck granules, the Langerhans cell hallmark organelle, and may have a preventive role ...
Thepaut, M. +11 more
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Langerin‐expressing dendritic cells in gut‐associated lymphoid tissues
Immunological Reviews, 2010Summary: Dendritic cells (DCs) are key regulators of the immune system. They act as professional antigen‐presenting cells and are capable of activating naive T cells and stimulating the growth and differentiation of B cells. According to their molecular expression, DCs can be divided into several subsets with different functions.
Sun-Young Chang, Mi-Na Kweon
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