Results 181 to 190 of about 8,253 (208)

Asymmetrically Branched Precision Glycooligomers Targeting Langerin

Biomacromolecules, 2019
Asymmetrically branched precision glycooligomers are synthesized by solid-phase polymer synthesis for studying multivalent carbohydrate-protein interactions. Through the stepwise assembly of Fmoc-protected oligo(amidoamine) building blocks and Fmoc/Dde-protected lysine, straightforward variation of structural parameters such as the number and length of
Kira Neuhaus, Eike-Christian Wamhoff, Tanja Freichel, Andrea Grafmüller, Christoph Rademacher, Laura Hartmann   +5 more
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Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin [PDF]

Immunological Reviews, 2010
Summary:  Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis. By electron microscopy, their identifying feature is the unique rod‐ or tennis racket‐shaped Birbeck granule.
Nikolaus Romani, B E Clausen, Patrizia Stoitzner   +2 more
exaly   +3 more sources

High affinity sugar ligands of C-type lectin receptor langerin

Biochimica Et Biophysica Acta - General Subjects, 2018
Langerin, a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs), binds to glycan ligands for pathogen capture and clearance. Previous studies revealed that langerin has an unusual binding affinity toward 6-sulfated galactose (Gal), a structure primarily found in keratan sulfate (KS).
Yasuhiko Kizuka, Yoshiki Yamaguchi, Masahiro Nagata   +2 more
exaly   +4 more sources

¹⁹F NMR-Guided Design of Glycomimetic Langerin Ligands

ACS Chemical Biology, 2016
C-type lectin receptors (CLRs) play a pivotal role in pathogen defense and immune homeostasis. Langerin, a CLR predominantly expressed on Langerhans cells, represents a potential target receptor for the development of anti-infectives or immunomodulatory therapies.
Wamhoff, E., Hanske, J., Schnirch, L., Aretz, J., Grube, M., Varón Silva, D., Rademacher, C.   +6 more
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Intestinal Regulation of C. albicans by PP Langerin+ DCs

The Journal of Immunology, 2017
Abstract As the largest mucosal compartment, the human gastrointestinal tract (GI) is highly colonized with a complex microbial ecosystem that includes fungal organisms. Although fewer in numbers and less extensively studied in the context of the intestinal mucosa, it is unclear whether commensal members such as Candida species play a ...
Magdia De Jesus, Emily Rochac-Argueta, Heather Gallagher   +2 more
openaire   +1 more source

Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin

Biochemistry, 2016
Langerin, a C-type lectin, is expressed in Langerhans cells. It was reported that langerin binds sulfated glycans, which is an important initial step for its role in blocking human immunodeficiency virus (HIV) transmission by capturing HIV pathogens and mediating their internalization into Birbeck granules for their elimination.
Jing, Zhao, Xinyue, Liu, Chelsea, Kao, Emily, Zhang, Quanhong, Li, Fuming, Zhang, Robert J, Linhardt   +6 more
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Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model

Biochemistry, 2009
Dendritic cells, a sentinel immunity cell lineage, include different cell subsets that express various C-type lectins. For example, epidermal Langerhans cells express langerin, and some dermal dendritic cells express DC-SIGN. Langerin is a crucial component of Birbeck granules, the Langerhans cell hallmark organelle, and may have a preventive role ...
Thepaut, M., Valladeau, J., Nurisso, A., Kahn, R., Arnou, B., Vives, C., Saeland, S., Ebel, C., Monnier, C., Dezutter-Dambuyant, C., Imberty, A., Fieschi, F.   +11 more
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Langerin-expressing and CD83-expressing cells in oral lichen planus lesions

Acta Odontologica Scandinavica, 2007
Dendritic Langerhans cells (LCs) have been attributed a role in the pathogenesis of lichen planus as autoantigen-presenting cells initiating expansion of autoreactive T cells. Langerin and CD83, which are cell molecules expressed on LCs, are associated with antigen presentation.
Jenny, Gustafson, Christina, Eklund, Mats, Wallström, Göran, Zellin, Bengt, Magnusson, Bengt, Hasséus   +5 more
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Gene Polymorphisms of CD207 (Langerin) Are Associated With End-Stage Renal Disease

Transplantation Proceedings, 2016
The CD207 molecule, also known as langerin, is known to be the first immunologic barrier expressed on Langerhans cells, which are the immature dendritic cells of the epidermis and mucosa. Inflammation could be a causal factor in the progression of chronic kidney disease.
B-W, Kim, S-W, Kang, Y-H, Kim
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Dectin-1 and langerin

Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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