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Calcium-Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides [PDF]
ChemBioChem, 2017 AbstractThe C‐type lectin receptor Langerin is a glycan‐binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most Langerin ligands are recognized by a canonical Ca2+‐dependent binding site, heparins have been proposed to make additional contacts to a secondary, Ca2 ...
Christoph Rademacher +2 more
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Langerin Is a Natural Barrier to HIV-1 Transmission by Langerhans Cells
Nature Medicine, 2007Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1.
Yvette van Kooyk +2 more
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Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin
Biochemistry, 2016Langerin, a C-type lectin, is expressed in Langerhans cells. It was reported that langerin binds sulfated glycans, which is an important initial step for its role in blocking human immunodeficiency virus (HIV) transmission by capturing HIV pathogens and mediating their internalization into Birbeck granules for their elimination.
Jing, Zhao +6 more
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High Affinity Sugar Ligands of C-Type Lectin Receptor Langerin
Biochimica Et Biophysica Acta - General Subjects, 2018Langerin, a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs), binds to glycan ligands for pathogen capture and clearance. Previous studies revealed that langerin has an unusual binding affinity toward 6-sulfated galactose (Gal), a structure primarily found in keratan sulfate (KS).
Naoyuki Taniguchi +2 more
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Structural Studies of Langerin and Birbeck Granule: A Macromolecular Organization Model
Biochemistry, 2009Dendritic cells, a sentinel immunity cell lineage, include different cell subsets that express various C-type lectins. For example, epidermal Langerhans cells express langerin, and some dermal dendritic cells express DC-SIGN. Langerin is a crucial component of Birbeck granules, the Langerhans cell hallmark organelle, and may have a preventive role ...
Thepaut, M. +11 more
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Intestinal Regulation of C. albicans by PP Langerin+ DCs
The Journal of Immunology, 2017Abstract As the largest mucosal compartment, the human gastrointestinal tract (GI) is highly colonized with a complex microbial ecosystem that includes fungal organisms. Although fewer in numbers and less extensively studied in the context of the intestinal mucosa, it is unclear whether commensal members such as Candida species play a ...
Magdia De Jesus +2 more
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Langerin‐expressing dendritic cells in gut‐associated lymphoid tissues
Immunological Reviews, 2010Summary: Dendritic cells (DCs) are key regulators of the immune system. They act as professional antigen‐presenting cells and are capable of activating naive T cells and stimulating the growth and differentiation of B cells. According to their molecular expression, DCs can be divided into several subsets with different functions.
Sun-Young, Chang, Mi-Na, Kweon
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Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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New aspects of langerin dendritic cells in patients with COPD
Airway Cell Biology and Immunopathology, 2017Background: Alveolar antigen uptake has remained poorly investigated in human lungs and it is unclear to what extent dendritic cell (DC) subsets are altered in the alveolar parenchyma of patients with COPD. Objectives: To assess the distribution and marker profile of DCs in distal lungs of patients with COPD.
Michiko Mori +5 more
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Studying the relationship of annexin A2, langerin, and Birbeck granules
2018Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), unique cytoplasmic organelles comprised of the c-type lectin langerin.
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