Results 61 to 70 of about 1,157,470 (266)
Individual variability and the H* ~ L + H* contrast in English
Language and CognitionThe H* ~ L + H* pitch accent contrast in English has been a matter of lengthy debate, with some arguing that L + H* is an emphatic version of H* and others that the accents are phonetically and pragmatically distinct.
Riccardo Orrico +3 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Impact of Formal and Informal Pronouns of Address on Product Price Estimation
LanguagesPrevious literature has examined the effect of using a formal or informal second-person pronoun on consumers’ appreciation of an advertisement and the advertised product and their purchase intention. This is the first study that additionally examines the
Helen de Hoop +5 more
doaj +1 more source
Sign Language Studies with Chimpanzees in Sanctuary. [PDF]
Animals (Basel), 2023 Jensvold ML, Dombrausky K, Collins E.
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Digital Tactics of Refugee Women: Towards an Inclusive Framework for Digital Literacies
Social InclusionThis article examines the complex relationship between online and offline inequalities for shaping refugee women’s experiences during resettlement. Refugee women have unique challenges during resettlement, yet the role of gender in shaping refugees ...
Amber I Bartlett +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Frontiers in Psychology, 2018 We conducted three neighborhood experiments with Dutch–English bilinguals to test effects of L2 proficiency and neighborhood characteristics within and between languages.
Kimberley Mulder +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source