Results 51 to 60 of about 198,713 (266)
Stages of teaching students a second foreign language based on cognitive communicative approach
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2020 Educators should carefully plan their teaching activities especially when it comes to second foreign language teaching. One of the most common problems many students face when learning a second foreign language is a negative language transfer which ...
N. A. Borozdina
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
LEXICAL COMPETENCE IN LEARNING SLOVENIAN AS A NON-FIRST LANGUAGE: A CASE STUDY
FilologThis paper analyzes the lexical competence of Bosnian, Montenegrin, and Serbian immigrants in learning Slovene as a non-first language. The theoretical section outlines how, with increasing language proficiency, both the range of vocabulary and control ...
Jana Lovrec Srša, Gjoko Nikolovski
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Polish as a foreign language at elementary level of instruction : crosslinguistic influences in writing [PDF]
Linguística, 2007 Being a minority European language, Polish has not attracted the attention of second language research (SLA) very much. Most studies in the area focus on English and other major languages describing variables and process observed in learners ...
Danuta Gabrys-Barker
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Orbis Scholae, 2018 The following contribution analyzes language transfer promoting instruction in the context of English as a foreign language (EFL) instruction in 9th grade secondary classes in Germany.
Kerstin Göbel, Svenja Vieluf
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