Results 171 to 180 of about 17,586 (206)

Alteration of Lipid Metabolism in Patients with IPF and Its Association with Disease Severity and Prognosis: A Case-Control Study. [PDF]

Int J Mol Sci
Faverio P, Rebora P, Franco G, Amato A, Corti N, Cattaneo K, Spiti S, Zanini U, Maloberti A, Giannattasio C, Luppi F, Leoni V.   +11 more
europepmc   +1 more source

Biomimetic syntheses of kadcoccitane H and kadcotrione C methyl ester. [PDF]

Chem Sci
Dethe DH, Siddiqui SA, Singha C.
europepmc   +1 more source

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Lanosterol biosynthesis in plants

Archives of Biochemistry and Biophysics, 2006
Plants biosynthesize sterols from cycloartenol using a pathway distinct from the animal and fungal route through lanosterol. Described herein are genome-mining experiments revealing that Arabidopsis encodes, in addition to cycloartenol synthase, an accurate lanosterol synthase (LSS)--the first example of lanosterol synthases cloned from a plant.
Mariya D, Kolesnikova, Quanbo, Xiong, Silvia, Lodeiro, Ling, Hua, Seiichi P T, Matsuda   +4 more
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23ξ-hydroxy-lanosterol

Tetrahedron, 1968
Abstract Extraction of the peridium of Scleroderma Aurantium yields a new dihydroxy tetracyclic triterpene of the lanostane series-23ξ-hydroxylanosterol(I).
N. Entwistle, A.D. Pratt
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Biosynthetic Mechanism of Lanosterol: Cyclization

Angewandte Chemie, 2015
AbstractThe remarkable cyclization mechanism of the formation of the 6‐6‐6‐5 tetracyclic lanosterol (a key triterpenoid intermediate in the biosynthesis of cholesterol) from the acyclic 2,3‐oxidosqualene catalyzed by oxidosqualene cyclase (OSC) has stimulated the interest of chemists and biologists for over a half century.
Nanhao, Chen, Shenglong, Wang, Lidia, Smentek, B Andes, Hess, Ruibo, Wu   +4 more
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Bioinspired Synthesis of Spirochensilide A from Lanosterol

Journal of the American Chemical Society, 2022
A bioinspired synthesis of spirochensilide A from commercially available lanosterol is reported. The synthesis features a directed C-H oxidation, a Wagner-Meerwein-type double methyl migration, a Meinwald rearrangement, and a double-bond isomerization/spiroketal formation cascade.
Xianwen Long, Jun Li, Feng Gao, Hai Wu, Jun Deng   +4 more
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Degradation of the lanosterol side-chain

Tetrahedron Letters, 1970
3β-Acetoxylanosta-8,24-diene (1) has been converted by a six-step degradation into 3β-acetoxy-4,4,14α-tri-methyl-5α-pregn-8-en-2-one (14).
L H, Briggs, J P, Bartley, P S, Rútledge   +2 more
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Lanosterol reverses protein aggregation in cataracts

Nature, 2015
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra- or inter-protein interactions will alter this delicate structure, exposing hydrophobic surfaces, with consequent protein aggregation and cataract formation.
Ling, Zhao, Xiang-Jun, Chen, Jie, Zhu, Yi-Bo, Xi, Xu, Yang, Li-Dan, Hu, Hong, Ouyang, Sherrina H, Patel, Xin, Jin, Danni, Lin, Frances, Wu, Ken, Flagg, Huimin, Cai, Gen, Li, Guiqun, Cao, Ying, Lin, Daniel, Chen, Cindy, Wen, Christopher, Chung, Yandong, Wang, Austin, Qiu, Emily, Yeh, Wenqiu, Wang, Xun, Hu, Seanna, Grob, Ruben, Abagyan, Zhiguang, Su, Harry Christianto, Tjondro, Xi-Juan, Zhao, Hongrong, Luo, Rui, Hou, J, Jefferson, P, Perry, Weiwei, Gao, Igor, Kozak, David, Granet, Yingrui, Li, Xiaodong, Sun, Jun, Wang, Liangfang, Zhang, Yizhi, Liu, Yong-Bin, Yan, Kang, Zhang   +42 more
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Lanosterol derivatives from phellinus torulosus

Phytochemistry, 1994
1523
González, Antonio G., Expósito, Teresa Siverio, Toledo Marante, Francisco J., Mediavilla Pérez, María Jesús, Tejera, Esperanza Beltrán, Bermejo Barrera, Jaime   +5 more
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Structures of some lanosterol derivatives

Acta Crystallographica Section C Crystal Structure Communications, 1989
I: C 32 H 54 O 4 cristallise dans P2 1 avec affinement jusqu'a 0,089. II: C 32 H 54 O 4 cristalise dans P2 1 2 1 2 1 avec affinement jusqu'a 0,086. III: C 32 H 50 O 6 cristallise dans C 2 avec affinement jusqu'a 0,084.
E. E. Castellano, J. Zukerman-Schpector, V. L. G. Rehder, A. J. Marsaioli   +3 more
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