Results 181 to 190 of about 17,625 (221)
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Position of the Hydroxyl Group in Lanosterol
Nature, 1949DEHYDRATION of alcohols of the lanosterol series to the corresponding hydrocarbons has recently been reported by us1, when the action of both phosphorus pentachloride and phosphorus oxychloride was described. Dihydroagnosterol and dihydrolanosterol, when treated with phosphorus pentachloride, gave iso-agnostadiene (‘iso-γ-lanostatriene'), C30H48, and ...
C, DOREE, J F, McGHIE, F, KURZER
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Bioinspired Synthesis of Spirochensilide A from Lanosterol
Journal of the American Chemical Society, 2022A bioinspired synthesis of spirochensilide A from commercially available lanosterol is reported. The synthesis features a directed C-H oxidation, a Wagner-Meerwein-type double methyl migration, a Meinwald rearrangement, and a double-bond isomerization/spiroketal formation cascade.
Xianwen Long +4 more
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Degradation of the lanosterol side-chain
Tetrahedron Letters, 19703β-Acetoxylanosta-8,24-diene (1) has been converted by a six-step degradation into 3β-acetoxy-4,4,14α-tri-methyl-5α-pregn-8-en-2-one (14).
L H, Briggs +2 more
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Equilibration of 24,25-dibromides of lanosterol and derivatives
Journal of the Chemical Society, Perkin Transactions 1, 1972Bromination of lanosteryl acetate under conditions of kinetic control gives two 24,25-dibromides. A and B, in equal amounts. Thermodynamically controlled equilibration of these dibromides results in a 5:1 mixture of the two. The driving force is considered to be interaction between the 20-methyl group and the 24-bromine atom in the 24R-configuration ...
D H, Barton +4 more
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Tetrahedron, 1968
Abstract Extraction of the peridium of Scleroderma Aurantium yields a new dihydroxy tetracyclic triterpene of the lanostane series-23ξ-hydroxylanosterol(I).
N. Entwistle, A.D. Pratt
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Abstract Extraction of the peridium of Scleroderma Aurantium yields a new dihydroxy tetracyclic triterpene of the lanostane series-23ξ-hydroxylanosterol(I).
N. Entwistle, A.D. Pratt
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Post-lanosterol biosynthesis of cholesterol and cancer
Current Opinion in Pharmacology, 2012Mammalian cells require cholesterol for proliferation. Cholesterol contributes not only to the physicochemical properties of membranes but also to the organization of lipid rafts involved in signal transduction. Inhibition of cholesterol biosynthesis from lanosterol results in the inhibition of cell cycle progression and, in certain cell types, also in
Miguel A, Lasunción +3 more
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Epoxides of lanosterol and some related compounds
Journal of the Chemical Society, Perkin Transactions 1, 1972A convenient method for the separation of the two isomers of 24ξ,25-epoxy-5α-lanost-8-en-3β-yl acetate is described. The absolute configuration of these compounds is established by their conversion into the corresponding 5α-lanost-8-ene-3β,24ξ-diol 3-acetates, and thence by Horeau's method (treatment with α-phenylbutyric anhydride), and by the method ...
R B, Boar, D A, Lewis, J F, McGhie
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Structures of some lanosterol derivatives
Acta Crystallographica Section C Crystal Structure Communications, 1989I: C 32 H 54 O 4 cristallise dans P2 1 avec affinement jusqu'a 0,089. II: C 32 H 54 O 4 cristalise dans P2 1 2 1 2 1 avec affinement jusqu'a 0,086. III: C 32 H 50 O 6 cristallise dans C 2 avec affinement jusqu'a 0,084.
E. E. Castellano +3 more
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Cholesterol Biosynthesis: Lanosterol to Cholesterol
Journal of Chemical Education, 2002Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration.
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