Results 171 to 180 of about 17,625 (221)

In Vivo and In Silico Evaluation of Analgesic and Hypoglycemic Activities of Methanolic Extract of <i>Codariocalyx gyroids</i>. [PDF]

Food Sci Nutr
Sultana N, Hasan M, Arabi II, Islam Z, Julhash J, Hani U, Sikder A, Khanam MA, Ripon A.   +8 more
europepmc   +1 more source

Acquired amphotericin B resistance attributed to a mutated <i>ERG3</i> in <i>Candidozyma auris</i>. [PDF]

Antimicrob Agents Chemother
Massic L, Doorley LA, Jones SJ, Richardson I, Siao DD, Siao L, Dykema P, Hua C, Schneider E, Cuomo CA, Rogers PD, Van Hooser S, Parker JE, Kelly SL, Hess D, Rybak JM, Pandori M.   +16 more
europepmc   +1 more source

Overcoming antifungal resistance in <i>Candida albicans via</i> RNA interference: a therapeutic perspective. [PDF]

Front Cell Infect Microbiol
Mundhe AK, Rajkumari R.
europepmc   +1 more source

Untargeted metabolomics reveals key metabolites and genes underlying salinity tolerance mechanisms in maize. [PDF]

Plant Genome
Brar MS, De Souza A, Ghai A, Ferreira JFS, Sandhu D, Sekhon RS.   +5 more
europepmc   +1 more source

ATR promotes mTORC1 activity via de novo cholesterol synthesis. [PDF]

EMBO Rep
Tangudu NK, Grumet AN, Fang R, Buj R, Cole AR, Uboveja A, Amalric A, Yang B, Huang Z, Happe C, Sun M, Gelhaus SL, MacDonald ML, Hempel N, Snyder NW, Kedziora KM, Valvezan AJ, Aird KM.   +17 more
europepmc   +1 more source

Identification of Cholesterol in Plaques of Atherosclerotic Using Magnetic Resonance Spectroscopy and 1D U-Net Architecture. [PDF]

Molecules
Myśliwiec A, Leksa D, Paul A, Xavierselvan M, Truszkiewicz A, Bartusik-Aebisher D, Aebisher D.   +6 more
europepmc   +1 more source

Genomic epidemiology of Colombian resistant <i>Candida auris</i> isolates. [PDF]

Antimicrob Agents Chemother
Alvarado Casas ML, Triana Díaz JA, Montilla-Escudero E, Prada Cardozo DA, Escandón Hernández P.   +4 more
europepmc   +1 more source

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Lanosterol biosynthesis in plants

Archives of Biochemistry and Biophysics, 2006
Plants biosynthesize sterols from cycloartenol using a pathway distinct from the animal and fungal route through lanosterol. Described herein are genome-mining experiments revealing that Arabidopsis encodes, in addition to cycloartenol synthase, an accurate lanosterol synthase (LSS)--the first example of lanosterol synthases cloned from a plant.
Seiichi P T Matsuda
exaly   +3 more sources

Biosynthetic Mechanism of Lanosterol: Cyclization

Angewandte Chemie - International Edition, 2015
AbstractThe remarkable cyclization mechanism of the formation of the 6‐6‐6‐5 tetracyclic lanosterol (a key triterpenoid intermediate in the biosynthesis of cholesterol) from the acyclic 2,3‐oxidosqualene catalyzed by oxidosqualene cyclase (OSC) has stimulated the interest of chemists and biologists for over a half century.
Nanhao Chen, Lidia Smentek, Ruibo Wu
exaly   +3 more sources

Lanosterol reverses protein aggregation in cataracts

Nature, 2015
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra- or inter-protein interactions will alter this delicate structure, exposing hydrophobic surfaces, with consequent protein aggregation and cataract formation.
Ling Zhao, Hong Ouyang, Xin Jin
exaly   +4 more sources