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Biosynthesis and Mode of Action of Lantibiotics
Chemical Reviews, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Champak Chatterjee +2 more
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Antonie van Leeuwenhoek, 1996
Bacteria producing bacteriocins have to be protected from being killed by themselves. This mechanism of self-protection or immunity is especially important if the bacteriocin does not need a specific receptor for its action, as is the case for the type A lantibiotics forming pores in the cytoplasmic membrane.
P E, Saris +3 more
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Bacteria producing bacteriocins have to be protected from being killed by themselves. This mechanism of self-protection or immunity is especially important if the bacteriocin does not need a specific receptor for its action, as is the case for the type A lantibiotics forming pores in the cytoplasmic membrane.
P E, Saris +3 more
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Current Protein & Peptide Science, 2008
Lantibiotics are a diverse family of bacterially synthesized antimicrobial peptides produced by gram-positive bacteria. They usually have a broad spectrum of targets, often including closely related strains. The production of lantibiotics must thus be coupled with a mechanism by which the producing strain can protect itself from the lethal action of ...
Lorraine A, Draper +3 more
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Lantibiotics are a diverse family of bacterially synthesized antimicrobial peptides produced by gram-positive bacteria. They usually have a broad spectrum of targets, often including closely related strains. The production of lantibiotics must thus be coupled with a mechanism by which the producing strain can protect itself from the lethal action of ...
Lorraine A, Draper +3 more
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The genetics of lantibiotic biosynthesis
BioEssays, 1995AbstractThe lantibiotics are a rapidly expanding group of biologically active peptides produced by a variety of Gram‐positive bacteria, and are so‐called because of their content of the thioether amino acids lanthionine and β‐methyllanthionine. These amino acids, and indeed a number of other unusual amino acids found in the lantibiotics, arise ...
R, Jack +3 more
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Protein engineering of lantibiotics
Antonie van Leeuwenhoek, 1996Whereas protein engineering of enzymes and structural proteins nowadays is an established research tool for studying structure-function relationships of polypeptides and for improving their properties, the engineering of posttranslationally modified peptides, such as the lantibiotics, is just coming of age.
Kuipers, O.P. +17 more
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Antimicrobial mechanism of lantibiotics
Biochemical Society Transactions, 2012Lantibiotics are ribosomally synthesized antimicrobial peptides that commonly target the cell wall precursor lipid II during their antimicrobial mechanism and exert their inhibitory activity by (i) inhibition of cell wall biosynthesis, and (ii) stable pore formation in the target membrane. Type-A(I) (i.e. nisin) and two-component (i.e.
Mohammad R, Islam +3 more
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Combination of Antibiotic Mechanisms in Lantibiotics
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Anja, Hoffmann +3 more
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Structure Revision of the Lantibiotic 97518
Journal of Natural Products, 2009The lantibiotic 97518, produced by a Planomonospora sp., was reported as a 2194 Da polypeptide comprising 24 amino acid residues with five thioether bridges. It was assigned to the mersacidin subgroup of type B lantibiotics by Castiglione et al. (Biochemistry 2007, 46, 5884-5897) and named planosporicin.
MAFFIOLI, SONIA ILARIA +8 more
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The solution structure of the lantibiotic gallidermin
Biopolymers, 1991AbstractThe 21‐peptide amide antibiotic gallidermin is a potential therapeutic against acne disease. It belongs to the class of polycyclic lanthionine and α,β‐clidehydroamino acids containing polypeptides, which were named “lantibiotics.” The structural gene of the recently elucidated lantibiotic gallidermin encodes a precursor peptide containing Ser ...
S, Freund +6 more
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Discovery of Medically Significant Lantibiotics
Current Drug Discovery Technologies, 2009The emergence of drug-resistant pathogens such as staphylococci and enterococci in the hospital setting has long being recognized as a serious clinical problem. Staphylococcus aureus is the causative agent of many nosocomial infections from minor skin abscesses to serious, potentially life threatening diseases such as bone and soft tissue intra ...
Clare, Piper +3 more
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