Results 61 to 70 of about 631,512 (303)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Al₂O₃/GeO₂/P₂O₅/F-Doped Silica Large-Mode-Area Optical Fibers for High-Power Single-Frequency Radiation Delivery

Photonics, 2023
A new design of a passive optical fiber waveguide with a large mode area (LMA) and strong stimulated Brillouin scattering (SBS) suppression is proposed. The fiber core consists of two parts: a central one, doped with Al2O3 and GeO2, and a peripheral one,
Sergey Tsvetkov, Alexey Lobanov, Denis Lipatov, Maxim Khudyakov, Tatiana Zaushitsyna, Liudmila Iskhakova, Leonid Kotov, Mikhail Likhachev   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Detailed Study of a Resonant-Assisted Segmented Cladding Fiber for Large Mode Area Applications

Photonics
In this work, we have proposed and optimized a large mode area segmented cladding fiber (SCF) with an unconventional low-index segment cladding. The low-refractive-index cladding proposed in this paper consists of three parts.
Minmin Xue, Hao Qin, Suwen Li, Yuqi Hao, Libo Yuan   +4 more
doaj   +1 more source

Characteristics and Laser Performance of Yb3+-Doped Silica Large Mode Area Fibers Prepared by Sol–Gel Method

Fibers, 2013
Large-size 0.1 Yb2O3–1.0 Al2O3–98.9 SiO2 (mol%) core glass was prepared by the sol–gel method. Its optical properties were evaluated. Both large mode area double cladding fiber (LMA DCF) with core diameter of 48 µm and large mode area photonic crystal ...
Shikai Wang, Fengguang Lou, Meng Wang, Chunlei Yu, Suya Feng, Qinling Zhou, Danping Chen, Lili Hu   +7 more
doaj   +1 more source

Refractivity of P₂O₅-Al₂O₃-SiO₂ Glass in Optical Fibers

Photonics, 2023
A significant change in the refractive index profiles for the large mode area phosphoroaluminosilicate (PAS) core optical fibers was observed in comparison to that in preforms.
Mikhail E. Likhachev, Tatiana S. Zaushitsyna, Vitaliya A. Agakhanova, Liudmila D. Iskhakova, Svetlana S. Aleshkina, Mikhail M. Bubnov, Alexey S. Lobanov, Denis S. Lipatov   +7 more
doaj   +1 more source

Efficient harmonic generation with large-mode-area fiber sources

Technical Digest. Summaries of Papers Presented at the Conference on Lasers and Electro-Optics. Conference Edition. 1998 Technical Digest Series, Vol.6 (IEEE Cat. No.98CH36178), 1998
We present the results of a series of experiments using doped fiber sources in which we have, to the best of our knowledge, demonstrated the highest ever pulse energies from a Q-switched fiber laser (180 /spl mu/J), the high second-harmonic conversion efficiency from a single pass in PPLN (periodically poled LiNbO/sub 3/) (83%), and the first ...
Britton, P.E., Richardson, D.J., Taverner, D., Smith, P.G.R., Ross, G.W., Hanna, D.C.   +5 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Steady-periodic method for modeling mode instability in fiber amplifiers

, 2013
We present a detailed description of the methods used in our model of mode instability in high-power, rare earth-doped, large-mode-area fiber amplifiers.
Smith, Arlee V., Smith, Jesse J.
core   +1 more source

Large mode area fibers with asymmetric bend compensation

Optics Express, 2011
Fibers with asymmetrical bend compensation offer to completely remove the tradeoff between mode area and single-modedness, with potentially huge impact on high-power amplification. These fibers would be difficult to fabricate, but are the only fundamental-mode strategy that can remove the bend-distortion limitations on mode-area scaling.
openaire   +2 more sources