Results 71 to 80 of about 618,573 (283)

Steady-periodic method for modeling mode instability in fiber amplifiers

, 2013
We present a detailed description of the methods used in our model of mode instability in high-power, rare earth-doped, large-mode-area fiber amplifiers.
Smith, Arlee V., Smith, Jesse J.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Anticrossing and Mode Coupling in Bent All-Glass Leakage Channel Microstructured Optical Fibers with Large Mode Area

Photonics
This paper presents the results of a detailed theoretical study of the bending properties of original all-glass leakage channel microstructured optical fibers (LC MOFs) over a bending radius range from 3 cm to 11 cm.
Alexander N. Denisov, Vladislav V. Dvoyrin, Sergey L. Semjonov   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Large mode area aperiodic fiber designs for robust singlemode emission under high thermal load

, 2015
International audienceIn this paper, we investigate the potential of various large mode area bers under thermal load, that is the state-of-the-art air-silica large pitch bers, as well as the recently devised symmetry-reduced photonic crystal ber and ...
Benoit, Aurélien, Coscelli, Enrico, Cucinotta, Annamaria, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Poli, Federica, Roy, Philippe, Salin, François, Schuster, Kay, Selleri, Stefano   +11 more
core   +2 more sources

Analysis of the modal content into large-mode-area photonic crystal fibers under heat load [PDF]

, 2015
International audienceThanks to their capability to provide very large mode area together with effective suppression of high-order modes, while allowing strong pump absorption and efficient conversion, Yb-doped double-cladding photonic crystal fibers are
Benoit, Aurélien, Coscelli, Enrico, Cucinotta, Annamaria, Darwich, Dia, Dauliat, Romain, Jamier, Raphaël, Poli, Federica, Roy, Philippe, Salin, François, Schuster, Kay, Selleri, Stefano   +10 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Optical Mode Calculation in Large-Area Photonic Crystal Surface-Emitting Lasers

IEEE Photonics Journal
We discuss algorithms and numerical challenges in constructing and resolving spectral problems for photonic crystal surface-emitting lasers (PCSELs) with photonic crystal layers and large (up to several tens of mm$^{2}$) emission areas.
Mindaugas Radziunas, Eduard Kuhn, Hans Wenzel, Ben King, Paul Crump   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source