Results 71 to 80 of about 631,512 (303)

Large mode area fiber lasers and their applications [PDF]

Advanced Solid State Lasers, 2000
The area of fiber lasers has undergone rapid developments in recent years. Gone are the days when fiber lasers were seen as something of an irrelevant curiosity, offering interesting performance features, but always with power levels or other performance limitations, that made them unsuitable for all but a few applications.
Richardson, D.J., Offerhaus, H.L., Broderick, N.G.R.   +2 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Anticrossing and Mode Coupling in Bent All-Glass Leakage Channel Microstructured Optical Fibers with Large Mode Area

Photonics
This paper presents the results of a detailed theoretical study of the bending properties of original all-glass leakage channel microstructured optical fibers (LC MOFs) over a bending radius range from 3 cm to 11 cm.
Alexander N. Denisov, Vladislav V. Dvoyrin, Sergey L. Semjonov   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Optical Mode Calculation in Large-Area Photonic Crystal Surface-Emitting Lasers

IEEE Photonics Journal
We discuss algorithms and numerical challenges in constructing and resolving spectral problems for photonic crystal surface-emitting lasers (PCSELs) with photonic crystal layers and large (up to several tens of mm$^{2}$) emission areas.
Mindaugas Radziunas, Eduard Kuhn, Hans Wenzel, Ben King, Paul Crump   +4 more
doaj   +1 more source

Large mode area aperiodic fiber designs for robust singlemode emission under high thermal load

, 2015
International audienceIn this paper, we investigate the potential of various large mode area bers under thermal load, that is the state-of-the-art air-silica large pitch bers, as well as the recently devised symmetry-reduced photonic crystal ber and ...
Benoit, Aurélien, Coscelli, Enrico, Cucinotta, Annamaria, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Poli, Federica, Roy, Philippe, Salin, François, Schuster, Kay, Selleri, Stefano   +11 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Energy Scaling of an Ultrafast All-PM-Fiber Laser Oscillator

IEEE Access, 2020
In this article we demonstrate the first, to the best of our knowledge, all-fiber self-starting laser oscillator consisting entirely of polarization-maintaining large mode area (PLMA) fibers mode-locked with nonlinear optical loop mirror (NOLM).
Mateusz Pielach, Bernard Piechal, Jan Szczepanek, Piotr Kabacinski, Yuriy Stepanenko   +4 more
doaj   +1 more source