Results 81 to 90 of about 618,573 (283)

Energy Scaling of an Ultrafast All-PM-Fiber Laser Oscillator

IEEE Access, 2020
In this article we demonstrate the first, to the best of our knowledge, all-fiber self-starting laser oscillator consisting entirely of polarization-maintaining large mode area (PLMA) fibers mode-locked with nonlinear optical loop mirror (NOLM).
Mateusz Pielach, Bernard Piechal, Jan Szczepanek, Piotr Kabacinski, Yuriy Stepanenko   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Single-Mode Operation in Flat Fibers Slab Waveguide via Modal Leakage

IEEE Photonics Journal, 2017
An approach to obtain single-mode operation on a semirectangular large core area Flat Fiber (FF) slab waveguide is proposed. A new design of FF with two defect eye holes is presented, and its single-mode guiding is analyzed by simulation. To validate the
Soo Yong Poh, Ghafour Amouzad Mahdiraji, Yong Meng Sua, Fatemeh Amirkhan, Din Chai Tee, Kwok Shien Yeo, Faisal Rafiq Mahamd Adikan   +6 more
doaj   +1 more source

Microstructured cladding elements to enhance performance and flexibility of large mode area leakage channel fibers

Large mode area fibers are imperative for scaling up the average power of fiber lasers. Single-mode behavior and low FM loss are the crucial functionalities for these fibers.
Baskiotis, C., Dasgupta, S., Hayes, J.R., Richardson, D.J.   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Toward a compact fibered squeezing parametric source

, 2018
In this work, we investigate three different compact fibered systems generating vacuum squeezing that involve optical cavities limited by the end surface of a fiber and by a curved mirror and containing a thin parametric crystal.
Brieussel, Alexandre, Fabre, Claude, Joos, Maxime, Ott, Konstantin, Treps, Nicolas   +4 more
core   +1 more source

Co-axial dual-core resonant leaky fibre for optical amplifiers [PDF]

, 2008
We present a co-axial dual-core resonant leaky optical fibre design, in which the outer core is made highly leaky. A suitable choice of parameters can enable us to resonantly couple power from the inner core to the outer core. In a large-core fibre, such
Ajeet Kumar, Arbore M A, Bachmann P K, Bernard Dussardier, Bise R T Fini J M Yan M F, Charu Kakkar, Kumar A, Li K, Vipul Rastogi, Yeung A Chiang K S Rastogi V Chu P L Peng G D   +9 more
core   +4 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Inner cladding influence on large mode area photonic crystal fiber properties under severe heat load

, 2016
International audienceThe influence of the size and the air-filling fraction of the inner microstructure on the first HOM confinement in Yb-doped LMA PCFs under different heat load values has been investigated with a full-vector modal solver based on the
Benoit, Aurélien, Coscelli, Enrico, Cucinotta, A, Darwich, Dia, Dauliat, Romain, Jamier, Raphaël, Poli, Federica, Roy, Philippe, Salin, François, Schuster, Kay, Selleri, S   +10 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source