Analysis of the modal content into large-mode-area photonic crystal fibers under heat load [PDF]
International audienceThanks to their capability to provide very large mode area together with effective suppression of high-order modes, while allowing strong pump absorption and efficient conversion, Yb-doped double-cladding photonic crystal fibers are
Benoit, Aurélien +10 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Single-Mode Operation in Flat Fibers Slab Waveguide via Modal Leakage
An approach to obtain single-mode operation on a semirectangular large core area Flat Fiber (FF) slab waveguide is proposed. A new design of FF with two defect eye holes is presented, and its single-mode guiding is analyzed by simulation. To validate the
Soo Yong Poh +6 more
doaj +1 more source
Highly sensitive refractometer with photonic crystal fiber long-period grating
We present highly sensitive refractometers based on a long-period grating in a large mode area PCF. The maximum sensitivity is 1500 nm/RIU at a refractive index of 1.33, the highest reported for any fiber grating.
Bang, Ole, Rindorf, Lars
core +1 more source
Co-axial dual-core resonant leaky fibre for optical amplifiers [PDF]
We present a co-axial dual-core resonant leaky optical fibre design, in which the outer core is made highly leaky. A suitable choice of parameters can enable us to resonantly couple power from the inner core to the outer core. In a large-core fibre, such
Ajeet Kumar +9 more
core +4 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Large mode area fibers are imperative for scaling up the average power of fiber lasers. Single-mode behavior and low FM loss are the crucial functionalities for these fibers.
Baskiotis, C. +3 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Inner cladding influence on large mode area photonic crystal fiber properties under severe heat load
International audienceThe influence of the size and the air-filling fraction of the inner microstructure on the first HOM confinement in Yb-doped LMA PCFs under different heat load values has been investigated with a full-vector modal solver based on the
Benoit, Aurélien +10 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source

