Results 91 to 100 of about 3,127,622 (352)

Tomographic Alcock–Paczyński Test with Redshift-space Correlation Function: Evidence for the Dark Energy Equation-of-state Parameter w > −1

open access: yesThe Astrophysical Journal, 2023
The apparent shape of galaxy clustering depends on the adopted cosmology used to convert observed redshift to comoving distance, the r ( z ) relation, as it changes the line elements along and across the line of sight differently.
Fuyu Dong   +6 more
doaj   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

ShopSign: a Diverse Scene Text Dataset of Chinese Shop Signs in Street Views [PDF]

open access: yesarXiv, 2019
In this paper, we introduce the ShopSign dataset, which is a newly developed natural scene text dataset of Chinese shop signs in street views. Although a few scene text datasets are already publicly available (e.g. ICDAR2015, COCO-Text), there are few images in these datasets that contain Chinese texts/characters.
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

What do university rankings by fields rank? Exploring discrepancies between the organizational structure of universities and bibliometric classifications [PDF]

open access: yes, 2013
University rankings by fields are usually based on the research output of universities. However, research managers and rankings consumers expect to see in such fields a reflection of the structure of their own organizational institution. In this study we address such misinterpretation by developing the research profile of the organizational units of ...
arxiv   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The Duality of the Universe [PDF]

open access: yesarXiv, 2008
It is proposed that the physical universe is an instance of a mathematical structure which possesses a dual structure, and that this dual structure is the collection of all possible knowledge of the physical universe. In turn, the physical universe is then the dual space of the latter.
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Galaxy Spin Transition Driven by the Misalignments between the Protogalaxy Inertia and Initial Tidal Tensors

open access: yesThe Astrophysical Journal
A numerical detection of the τ -driven transition of galaxy spins is presented, where τ is the degree of misalignment between the initial tidal field and protogalaxy inertia tensors.
Jun-Sung Moon, Jounghun Lee
doaj   +1 more source

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