Results 21 to 30 of about 16,605,417 (300)

AI-enabled language models (LMs) to large language models (LLMs) and multimodal large language models (MLLMs) in drug discovery and development

Journal of Advanced Research
Background: Due to the recent revolution of artificial intelligence (AI), AI-enabled large language models (LLMs) have flourished and started to be applied in various sectors of science and medicine.
Chiranjib Chakraborty, Manojit Bhattacharya, Soumen Pal, Srijan Chatterjee, Arpita Das, Sang-Soo Lee   +5 more
doaj   +1 more source

Diagram-based Input for Large Language Models to Support Accessible STEM Learning [PDF]

, 2023
To meet the accessibility needs of students who are blind or have low vision (BLV), detailed textual descriptions of STEM diagrams within interactive learning tools are cre-ated in real-time and correspond to the configurations of the interactive ...
Julia, Winter, Alexa, Urrea, Sarah E., Wegwerth   +2 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

From Large Language Models to Large Multimodal Models: A Literature Review

Applied Sciences
With the deepening of research on Large Language Models (LLMs), significant progress has been made in recent years on the development of Large Multimodal Models (LMMs), which are gradually moving toward Artificial General Intelligence. This paper aims to
Dawei Huang, Chuan Yan, Qing Li, Xiaojiang Peng   +3 more
doaj   +1 more source

Large language models propagate race-based medicine

npj Digital Medicine, 2023
Large language models (LLMs) are being integrated into healthcare systems; but these models may recapitulate harmful, race-based medicine. The objective of this study is to assess whether four commercially available large language models (LLMs) propagate
Jesutofunmi A. Omiye, Jenna C. Lester, Simon Spichak, Veronica Rotemberg, Roxana Daneshjou   +4 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Large language models in medicine

Nature Medicine, 2023
Large language models (LLMs) can respond to free-text queries without being specifically trained in the task in question, causing excitement and concern about their use in healthcare settings. ChatGPT is a generative artificial intelligence (AI) chatbot produced through sophisticated fine-tuning of an LLM, and other tools are emerging through similar ...
Thirunavukarasu, Arun James, Ting, Darren Shu Jeng, Elangovan, Kabilan, Gutierrez, Laura, Tan, Ting Fang, Ting, Daniel Shu Wei   +5 more
openaire   +2 more sources

Language Without Propositions: Why Large Language Models Hallucinate

Philosophies
This paper defends the thesis that LLM hallucinations are best explained as a truth representation problem: Current models lack an internal representation of propositions as truth-bearers, so truth and falsity cannot constrain generation in the way ...
Jakub Mácha
doaj   +1 more source