Results 61 to 70 of about 450,572 (276)

An Improved Large Neighborhood Search for Network-Level Airport Slot Allocation Optimization

IEEE Access
Airports worldwide face a significant gap between capacity and demand. As a short-term solution, the International Air Transport Association has implemented schedule coordination rules at busy airports.
Qiangzhe Wang, Yuanyuan Ma, Yifan Xu, Zhiyuan Shen, Dan Li   +4 more
doaj   +1 more source

Adaptive Large Neighborhood Search Metaheuristic for the Capacitated Vehicle Routing Problem with Parcel Lockers

Logistics, 2023
Background: The growth of e-commerce necessitates efficient logistics management to address rising last-mile delivery challenges. To overcome some of the last-mile delivery costs, parcel lockers as a delivery option, can be an alternative solution.
Amira Saker, Amr Eltawil, Islam Ali
doaj   +1 more source

A Note on Inhomogeneous Ground States at Large Global Charge [PDF]

, 2017
In this note we search for the ground state, in infinite volume, of the $D=3$ Wilson-Fisher conformal $O(4)$ model, at nonzero values of the two independent charge densities $\rho_{1,2}$.
Hellerman, Simeon, Kobayashi, Nozomu, Maeda, Shunsuke, Watanabe, Masataka   +3 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Parallel Hybrid Trajectory Based Metaheuristics for Real-World Problems [PDF]

, 2015
G. Luque, E. Alba, Parallel Hybrid Trajectory Based Metaheuristics for Real-World Problems, In Proceedings of Intelligent Networking and Collaborative Systems, pp.
Alba-Torres, Enrique, Luque-Polo, Gabriel Jesús   +1 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Adaptive Large Neighborhood Search for a Production Planning Problem Arising in Pig Farming

Journal of Open Innovation: Technology, Market and Complexity, 2019
. This article aims to resolve a particular production planning and workforce assignment problem. Many production lines may have different production capacities while producing the same product. Each production line is composed of three production stages,
Nat Praseeratasang, Rapeepan Pitakaso, Kanchana Sethanan, Sasitorn Kaewman, Paulina Golinska-Dawson   +4 more
doaj   +1 more source

Very Large-Scale Neighborhood Search for the Quadratic Assignment Problem [PDF]

SSRN Electronic Journal, 2002
The quadratic assignment problem (QAP) consists of assigning n facilities to n locations to minimize the total weighted cost of interactions between facilities. The QAP arises in many diverse settings, is known to be NP-hard, and can be solved to optimality only for fairly small instances (typically, n ≤ 30).
Ahuja, Ravindra, Jha, Krishna, Orlin, James, Sharma, Dushyant   +3 more
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Generic Pareto local search metaheuristic for optimization of targeted offers in a bi-objective direct marketing campaign [PDF]

, 2016
Cross-selling campaigns seek to offer the right products to the set of customers with the goal of maximizing expected profit, while, at the same time, respecting the purchasing constraints set by investors. In this context, a bi-objective version of this
Coelho, B.N., Coelho, I.M., Coelho, V.N., Fleming, P.J., Guimaraes, F.G., Lust, T., Oliveira, T.A., Ramalhinho, H., Souza, M.J.F., Talbi, E-G.   +9 more
core   +3 more sources