Results 91 to 100 of about 10,005,809 (327)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Robustness of Cosmological Simulations I: Large Scale Structure

, 2004
The gravitationally-driven evolution of cold dark matter dominates the formation of structure in the Universe over a wide range of length scales. While the longest scales can be treated by perturbation theory, a fully quantitative understanding of ...
Abazajian K., Katrin Heitmann, Klypin A. A., Lacey C., Michael S. Warren, Mo H. J., Navarro J. F., Paul M. Ricker, Rosner R., Salman Habib, Zel’dovich Y. B.   +10 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

DESIGNING INTRINSICALLY SAFE FIBER-OPTIC SENSORS FOR MONITORING THE TECHNICAL CONDITION OF LARGE STRUCTURES

Надежность и качество сложных систем
Background. Monitoring the technical condition of responsible and potentially dangerous large civil and special structures, such as nuclear power plants, pipelines, bridges, and many others, in order to determine their operability and safe operation, and
E.A. Badeeva, V.A. Badeev, T.I. Murashkina   +2 more
doaj   +1 more source

Large-scale structure and hyperuniformity of amorphous ices

, 2017
We investigate the large-scale structure of amorphous ices and transitions between their different forms by quantifying their large-scale density fluctuations.
Car, Roberto, Giovambattista, Nicolas, Martelli, Fausto, Torquato, Salvatore   +3 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Large Scale Electronic Structure Calculations with Multigrid Acceleration

, 1995
We have developed a set of techniques for performing large scale ab initio calculations using multigrid accelerations and a real-space grid as a basis. The multigrid methods permit efficient calculations on ill-conditioned systems with long length scales
A. Brandt, A. Brandt, C. Kittel, D. J. Sullivan, D. W. Brenner, E. L. Briggs, F. Mauri, G. Galli, I. Stich, J. Bernholc, J. Bernholc, J. R. Chelikowsky, J. R. Chelikowsky, J. Tersoff, J. Tersoff, J. Tersoff, K. D. Brommer, M. C. Payne, P. Bogusławski, P. Ordejón, T. A. Arias, T. A. Arias, W. E. Pickett, W. L. Briggs, X. Jing   +24 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source