Results 91 to 100 of about 9,947,482 (276)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Large-scale structure in superfluid Chaplygin gas cosmology

, 2014
We investigate the growth of large-scale structure in the superfluid Chaplygin gas (SCG) model. Both linear and non-linear growth, such as $\sigma_8$ and the skewness $S_3$, are discussed. We find the growth factor of SCG reduces to the EdS case at early
Yang, Rong-Jia
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Model tests on disturbance characteristics of surrounding rock of loess shield tunnels during excavation

Yantu gongcheng xuebao
In order to explore the disturbance characteristics of the surrounding rock by excavation of loess shield tunnels under different water contents and buried depths, the similarity model tests are carried out.
HAN Xingbo 1, 2, CHEN Ziming 1, YE Fei 1, 2, LIANG Xiaoming 3, FENG Haolan 1, XIA Tianhan 1
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

DESIGNING INTRINSICALLY SAFE FIBER-OPTIC SENSORS FOR MONITORING THE TECHNICAL CONDITION OF LARGE STRUCTURES

Надежность и качество сложных систем
Background. Monitoring the technical condition of responsible and potentially dangerous large civil and special structures, such as nuclear power plants, pipelines, bridges, and many others, in order to determine their operability and safe operation, and
E.A. Badeeva, V.A. Badeev, T.I. Murashkina   +2 more
doaj   +1 more source

Robustness of Cosmological Simulations I: Large Scale Structure

, 2004
The gravitationally-driven evolution of cold dark matter dominates the formation of structure in the Universe over a wide range of length scales. While the longest scales can be treated by perturbation theory, a fully quantitative understanding of ...
Abazajian K., Katrin Heitmann, Klypin A. A., Lacey C., Michael S. Warren, Mo H. J., Navarro J. F., Paul M. Ricker, Rosner R., Salman Habib, Zel’dovich Y. B.   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source