Results 201 to 210 of about 180,806 (262)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Simultaneous three-photon and optical coherence microscopy deep within an intact mouse brain. [PDF]

Npj Imaging
Yang X, Liu S, Xia F, Wu M, Xu C, Adie SG.   +5 more
europepmc   +1 more source

Preparation of cleared whole-mount urethra and urinary bladder from transcardially perfused mice for immunolabeling and analysis by CLSM. [PDF]

STAR Protoc
Pfeil U, Dettler F, Perniss A, Anekal PV, Bankova L, Montero LIopis P, Deckmann K.   +6 more
europepmc   +1 more source

Non-diffusive slow heat dissipation induces high local temperature in living cells. [PDF]

Nat Commun
Takarada M, Shirakashi R, Takinoue M, Ishida M, Morita M, Noji H, Tabata KV, Funatsu T, Okabe K.   +8 more
europepmc   +1 more source

Mechanism of action of soybean oil in arthropods: mortality results from tracheal infiltration and obstruction of gas exchange structures. [PDF]

J Econ Entomol
Castro-Torres R, Valdez-Carrasco J, Rodríguez-Leyva E, Soto-Rojas L, Lomeli-Flores JR.   +4 more
europepmc   +1 more source

Antibiofilm activity of terbinafine, itraconazole and their combination against Sporothrix brasiliensis yeast-like form's biofilms. [PDF]

Braz J Microbiol
Sprenger AB, Svidzinski TIE, Geraldo MR, Silva AB, Sant Ana LAM, Cognialli RCR, Razzolini E, Santos GD, Vicente VA, Queiroz-Telles F.   +9 more
europepmc   +1 more source

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR. [PDF]

Nature
Ge D, Ortiz-Morea FA, Xie Y, Yeo IC, Shen Q, Zhou Y, Liu G, Kong L, Shan L, He P.   +9 more
europepmc   +1 more source

How the Confocal Laser Scanning Microscope entered Biological Research [PDF]

Biology of the Cell, 2003
AbstractA history of the early development of the confocal laser scanning microscope in the MRC Laboratory of Molecular Biology in Cambridge is presented. The rapid uptake of this technology is explained by the wide use of fluorescence in the 80s. The key innovations were the scanning of the light beam over the specimen rather than vice‐versa and a ...
W B Amos, J G White
exaly   +3 more sources

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The laser-scanning confocal vibrometer microscope

SPIE Proceedings, 2005
Sub-micrometer lateral resolution for the optical vibration measurement can be achieved when the scanned laser beam of a confocal microscope is the measurement beam of a heterodyne laser-Doppler vibrometer. Such a scanning system that allows vibration measurements up to 30 MHz is presented in this paper for the first time. We measured a minimum 1/e 2
Christian Rembe, Alexander Drabenstedt
openaire   +1 more source