Results 61 to 70 of about 14,758 (206)

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

A cluster of nosocomial Lassa fever cases in a tertiary health facility in Nigeria: Description and lessons learned, 2018

International Journal of Infectious Diseases, 2019
Background: Lassa fever is an acute viral haemorrhagic disease endemic in Nigeria. The 2018 Lassa fever outbreak in Nigeria was unprecedented, with 8% of all cases occurring among healthcare workers (HCWs).
Chioma C. Dan-Nwafor, Oladipupo Ipadeola, Elizabeth Smout, Elsie Ilori, Ayodele Adeyemo, Chukwuma Umeokonkwo, Damian Nwidi, Williams Nwachukwu, Winifred Ukponu, Emeka Omabe, Uchenna Anaebonam, Nneka Igwenyi, Gordon Igbodo, Womi Eteng, Ikemefule Uzoma, Muhammed Saleh, Joseph Agboeze, Samuel Mutbam, Tanyth de Gooyer, Rosie Short, Everistus Aniaku, Robinson Onoh, Emeka Ogah, Patrick Nguku, John Oladejo, Clement Peter, Olubunmi Ojo, Chikwe Ihekweazu   +27 more
doaj   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Pathogenesis of Lassa Fever

Viruses, 2012
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for ...
David H. Walker, Nadezhda E. Yun
doaj   +1 more source

Incorporating Machine Learning Techniques to Enhance Rodent Surveillance in Marginalized Urban Communities

Ecology and Evolution, Volume 15, Issue 11, November 2025.
Represent the in‐field design of the trackplates and analysis methods. ABSTRACT Effective management of rodent pests necessitates efficient population surveillance. Many of the available methods currently used for estimating rodent populations are either costly or time‐intensive. Rodent trapping demands significant resources, while tracking plates (TP)
Fabio Neves Souza, Adedayo Michael Awoniyi, Rodrigo Dalvit Carvalho da Silva, Nivison Nery Jr, Maria Victoria Moraes Oliveira, Caio Graco Zeppelini, George Andre Pereira Thé, Kathryn Hacker, Max T. Eyre, Hernan Dario Argibay, Albert Ko, Federico Costa, Hussein Khalil   +12 more
wiley   +1 more source

Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding [PDF]

, 2008
Background Sera from convalescent Lassa fever patients often contains antibodies to Lassa virus (LASV) glycoprotein 1 (GP1), and glycoprotein 2 (GP2); Immunization of non-human primates with viral vectors expressing the arenaviral glycoprotein complex ...
Illick Kerry A, Fair Joseph N, Branco Luis M, Illick Megan M, Matschiner Alex, Schoepp Randal, Garry Robert F, Guttieri Mary C   +7 more
core   +2 more sources

mRNA Vaccines: Current Applications and Future Directions

MedComm, Volume 6, Issue 11, November 2025.
mRNA vaccines represent an innovative platform that leverages messenger RNA technology to direct cells to produce specific antigens, thereby eliciting an immune response. mRNA vaccines offer high programmability and significantly improved stability and immunogenicity through nucleotide modifications and delivery systems such as lipid nanoparticles ...
Jianmei Li, Yixin Liu, Jie Dai, Li Yang, Feng Xiong, Jing Xia, Jing Jin, Yangping Wu, Xingchen Peng   +8 more
wiley   +1 more source

Outbreak of lassa fever in Nigeria: measures for prevention and control

The Pan African Medical Journal, 2016
Lassa fever, an acute viral haemorrhagic fever, extremely virulent and often infectious, occurs very frequently in different parts of Nigeria [1-4] and affects approximately 100,000-500,000 persons per year in West Africa.
Kehinde Charles Mofolorunsho
doaj   +1 more source

Data set on Lassa fever in post-conflict Sierra Leone

Data in Brief, 2019
Lassa fever is a rodent-borne illness that is endemic to parts of sub-Saharan Africa, including Sierra Leone, Nigeria, and Guinea. The disease is named after the town of Lassa, Nigeria where it was discovered in 1969.
Jeffrey G. Shaffer, John S. Schieffelin, Donald S. Grant, Augustine Goba, Mambu Momoh, Lansana Kanneh, Danielle C. Levy, Jessica N. Hartnett, Matt L. Boisen, Luis M. Branco, Robert F. Garry   +10 more
doaj   +1 more source

Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas

Biotropica, Volume 57, Issue 6, November 2025.
Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura, Oscar Rico‐Chavéz, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source