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Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development [PDF]

Viruses, 2020
Lassa virus (LASV), which causes considerable morbidity and mortality annually, has a high genetic diversity across West Africa. LASV glycoprotein (GP) expresses this diversity, but most LASV vaccine candidates utilize only the Lineage IV LASV Josiah strain GP antigen as an immunogen and homologous challenge with Lineage IV LASV.
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Immune Responses and Lassa Virus Infection [PDF]

Viruses, 2012
Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently ...
Sylvain Baize, Marion Russier, Baize Sylvain   +2 more
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Arenaviruses other than Lassa virus

Antiviral Research, 2003
The family Arenaviridae includes 23 viral species, of which 5 can cause viral hemorrhagic fevers with a case fatality rate of about 20%. These five viruses are Junin, Machupo, Guanarito, Sabia and Lassa virus, the manipulation of which requires biosafety level 4 facilities. They are included in the Category A Pathogen List established by the Center for
Rémi Charrel
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Lassa Virus Reverse Genetics

2017
The Old World (OW) arenavirus Lassa (LASV ) is estimated to infect several hundred thousand people yearly in West Africa, resulting in high numbers of Lassa fever (LF), a viral hemorrhagic fever (HF) disease associated with high morbidity and mortality.
Luis, Martínez-Sobrido, Slobodan, Paessler, Juan Carlos, de la Torre   +2 more
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Lassa Virus Hepatitis: a Study of Fatal Lassa Fever in Humans

The American Journal of Tropical Medicine and Hygiene, 1986
In order to explore the significance of a previous observation that the most important pathologic changes in fatal Lassa fever are hepatic, we have studied postmortem liver biopsies from 19 patients with fatal Lassa fever. We observed a vigorous macrophage response to cellular damage, but we found no evidence of lymphocyte infiltration in infected ...
J B, McCormick, D H, Walker, I J, King, P A, Webb, L H, Elliott, S G, Whitfield, K M, Johnson   +6 more
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Lassa Fever Virus

1973
Lassa fever is a virus disease of man characterized by generalized organ involvement resulting in manifestations of myositis, myocarditis, pneumonitis, encephalopathy, and signs of kidney involvement and hemorrhagic diathesis.
J. Casals, Sonja M. Buckley
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Standardization of a plaque assay for lassa virus

Journal of Medical Virology, 1987
AbstractThe plaque reduction neutralization test (PRNT) has been used routinely in serological studies with such arenaviruses as Junin, Machupo, and Parana. However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test with Lassa virus.
O, Tomori, K M, Johnson, M P, Kiley, L H, Elliott   +3 more
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Lassa Virus Structural Biology and Replication

2023
Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic fever that is endemic in West Africa. LASV virions are enveloped and contain two single-stranded RNA genome segments. Both segments are ambisense and encode two proteins. The nucleoprotein associates with viral RNAs forming ribonucleoprotein complexes. The glycoprotein
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Animal models for Lassa virus infection

Current Opinion in Virology, 2019
In humans, Lassa virus infection can result in disease with hemorrhagic manifestations and high fatality rates. There are no approved treatments or vaccines available and the inherent danger of studying Lassa virus means it can only be studied in high containment labs (BSL4).
Tsing-Lee, Tang-Huau, H, Feldmann, K, Rosenke   +2 more
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Isolation and Antigenic Characterization of Lassa Virus

Nature, 1970
LASSA fever as it was first noticed early in 1969 in three missionary nurses in Nigeria will be described by Frame et al.1. The disease later affected two laboratory workers at the Yale Arbovirus Research Unit (YARU) in New Haven. Two of the nurses and one of the laboratory workers died.
S M, Buckley, J, Casals, W G, Downs
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