Results 81 to 90 of about 16,901 (224)

Immunobiology of Ebola and Lassa virus infections [PDF]

Nature Reviews Immunology, 2017
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia.
Joseph B, Prescott, Andrea, Marzi, David, Safronetz, Shelly J, Robertson, Heinz, Feldmann, Sonja M, Best   +5 more
openaire   +2 more sources

A Systematic Review on the Economic Burden of the Most Prevalent Infectious Diseases in West Africa

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aim Infectious diseases, including malaria, tuberculosis, cholera, and Lassa fever, pose a significant public health and economic challenge in West Africa. The financial burden includes direct medical costs (hospitalization, medication, diagnostics), nonmedical costs (transportation, food, caregiving), and indirect costs (loss ...
Kofi Afriyie Nyamekye, Eric Sampane‐Donkor, Haruna Latif, Justice Moses K. Aheto   +3 more
wiley   +1 more source

Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

BMC Infectious Diseases, 2004
Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic fever (HF) viruses has emerged as a worldwide concern among public health officials ...
Tibbles Heather E, Vassilev Alexei O, Petkevich Alexander S, Uckun Fatih M, Titov Leonid   +4 more
doaj   +1 more source

Mutational Analysis of the Lassa Virus Promoter [PDF]

Journal of Virology, 2006
ABSTRACT The promoter sequences directing viral gene expression and genome replication of arenaviruses reside within the 3′ and 5′ termini of each RNA segment. The terminal 19 nucleotides at both ends are highly conserved among all arenavirus species and are almost completely complementary to each other. This study aimed at characterizing the
Meike, Hass, Martina, Westerkofsky, Stefanie, Müller, Beate, Becker-Ziaja, Carola, Busch, Stephan, Günther   +5 more
openaire   +2 more sources

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques

mBio, 2018
Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease.
Kathleen A. Cashman, Eric R. Wilkinson, Xiankun Zeng, Anthony P. Cardile, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Carl I. Shaia, Connie S. Schmaljohn   +8 more
doaj   +1 more source

A Unified Framework for the Infection Dynamics of Zoonotic Spillover and Spread. [PDF]

, 2016
A considerable amount of disease is transmitted from animals to humans and many of these zoonoses are neglected tropical diseases. As outbreaks of SARS, avian influenza and Ebola have demonstrated, however, zoonotic diseases are serious threats to global
Cunningham, Andrew A, Fichet-Calvet, Elisabeth, Garry, Robert F, Grant, Donald S, Leach, Melissa, Lo Iacono, Giovanni, Moses, Lina M, Nichols, Gordon, Schieffelin, John S, Shaffer, Jeffrey G, Webb, Colleen T, Wood, James LN   +11 more
core   +3 more sources

Views of Health Professionals on the Contribution of Climate Change to the Transmission of Lassa Fever in Nigeria and the Implications for Risk Communication

Advances in Public Health, Volume 2026, Issue 1, 2026.
Lassa fever is an acute viral haemorrhagic illness caused by the Lassa virus and is mainly spread through direct and indirect human–rodent interaction. In Nigeria, Lassa fever outbreaks are becoming more frequent, and studies suggest that changes in climatic and ecological conditions will exacerbate these trends. It is crucial that health professionals
Ibrahim Yusuf Eroje, Richard Philip Lee, Hannah Wesley   +2 more
wiley   +1 more source

Assessing the Environmental Drivers of Lassa Fever in West Africa: A Systematic Review

Viruses
The spread of Lassa virus in West Africa is reliant on the abundance and distribution of its rodent host reservoirs. While the impact of environmental change on viral spread has been studied for many zoonotic viruses, there is still a limited ...
Natalie A. Davis, Madeline A. Kenyon, Bruno M. Ghersi, Jessica L. Decker Sparks, Jonathon D. Gass   +4 more
doaj   +1 more source

Rat-atouille: A Mixed Method Study to Characterize Rodent Hunting and Consumption in the Context of Lassa Fever [PDF]

, 2016
Lassa fever is a zoonotic hemorrhagic illness predominant in areas across Nigeria, Sierra Leone, Guinea, Liberia, and southern Mali. The reservoir of Lassa virus is the multimammate mouse (Mastomys natalensis), a highly commensal species in West Africa ...
Almudena Mari Saez, Ann H. Kelly, Elisabeth Fichet-Calvet, Foday Sahr, Jesse Bonwitt, Matthias Borchert, Rashid Ansumana, Richard Kock, Schadrac Agbla   +8 more
core   +4 more sources