Results 101 to 110 of about 182,437 (357)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Two Circumpolar Ground Beetle Species (Coleoptera: Carabidae) Were in Hokkaido, Japan, Late in the Last Glacial Period

Quaternary
Fossilized body parts of two cold-adapted ground beetle species, Elaphrus lapponicus and Diacheila polita, were identified from a deposit dated to the Late Glacial period in Hokkaido, Japan.
Shigehiko Shiyake
doaj   +1 more source

Sea surface temperature changes in the southern California borderlands during the last glacial-interglacial cycle [PDF]

, 1996
A variety of evidence suggests that average sea surface temperatures (SSTs) during the last glacial maximum in the California Borderlands region were significantly colder than during the Holocene.
Bandy, Bard, Berelson, Berger, Bond, Bond, Bradshaw, Clark, CLIMAP Project Members, Climate: Long-Range Investigation, Cooperative Holocene Mapping Project (COHMAP) Members, Coulbourn, Dansgaard, David M. Anderson, Epstein, Fairbanks, Fairbanks, Fischer, Gorsline, Gorsline, Grootes, Hickey, Hickey, Hickey, Hutson, Huyer, Imbrie, Imbrie, Jahnke, Jianning Le, Kahn, Kennett, Kennett, Kheradpir, Lowell D. Stott, Martin, Martin, Martinson, McIntyre, Okada, Overpeck, P. Graham Mortyn, Prahl, Prell, Reynolds, Robert C. Thunell, Sautter, Sautter, Taylor, Thunell, Thunell, Thunell, Tont   +52 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. [PDF]

Nat Ecol Evol, 2022
Charlton S, Brace S, Hajdinjak M, Kearney R, Booth T, Reade H, Tripp JA, Sayle KL, Grimm SB, Bello SM, Walker EA, Gilardet A, East P, Glocke I, Larson G, Higham T, Stringer C, Skoglund P, Barnes I, Stevens RE.   +19 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Development of the late glacial Baltic basin and the succession of vegetation cover as revealed at Palaeolake Haljala, northern Estonia [PDF]

Estonian Journal of Earth Sciences, 2009
The 4.5 m thick Haljala sequence in North Estonia was studied to provide information on palaeoenvironmental changes between 13 800 and 11 300 cal yr BP.
Saarse, Leili, Niinemets, Eve, Amon, Leeli, Heinsalu, Atko, Veski, Siim, Sohar, Kadri   +5 more
doaj  

LATE GLACIAL AND HOLOCENE ENVIRONMENTAL CHANGE INFERRED FROM THE PÁRAMO OF CAJANUMA IN THE PODOCARPUS NATIONAL PARK, SOUTHERN ECUADOR

Caldasia, 2014
To reconstruct the environmental history including vegetation, fire and climate dynamics, from the Cajanuma valley area ( 3285 m elevation) in the Podocarpus National Park, southern Ecuador , we address the following major research question: (1) How did ...
ANDREA VILLOTA, HERMANN BEHLING
doaj   +1 more source

Summer paleohydrology during the Late Glacial and Early Holocene based on δ²H and δ¹⁸O from Bichlersee, Bavaria. [PDF]

Sci Rep, 2023
Prochnow M, Strobel P, Bliedtner M, Struck J, Bittner L, Szidat S, Salazar G, Schneider H, Acharya S, Zech M, Zech R.   +10 more
europepmc   +1 more source

Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe [PDF]

, 2015
Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level
Frogley, Michael R, Hughes, Philip D, Reed, Jane M, Tzedakis, Polychronis C, Wilson, Graham P   +4 more
core   +3 more sources