Results 71 to 80 of about 182,437 (357)

Application data base paleogeographic Kola peninsula «Q-KOLA» in paleolimnological research

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015
The paleogeographic database “Q-KOLA” was created to systematize, statistically analyze and visualize information about the history of the natural ecosystems of the Kola Peninsula in the Late Glacial and Holocene. The database can be used in limnological
Ivan Grekov, Dmitry Subetto
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Über Vorkommen „degradierter Steppenböden" in den Lößgebieten des Niederrheins und Westfalens und ihre Bedeutung für die Paläobodenkunde und Bodengenese [PDF]

Eiszeitalter und Gegenwart, 1965
The loess soils of the Lower Rhine area and of Westphalia partially present deep humic horizonts, the genesis of which was unknown. By the evaluation of elaborated soil estimation maps (M.
E. Kopp
doaj   +1 more source

Global late Quaternary megafauna extinctions linked to humans, not climate change [PDF]

, 2014
The late Quaternary megafauna extinction was a severe global-scale event. Two factors, climate change and modern humans, have received broad support as the primary drivers, but their absolute and relative importance remains controversial.
Boslough M, Brummitt RK, Corlett RT, Faunmap working group, Hasumi H, Kissling WD, Lyons SK, Martin PS, Martin PS, Nogués-Bravo D, Prado JL, R Development Core Team   +11 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The deglaciation of the mountains of Mexico and Central America

Cuadernos de Investigación Geográfica, 2017
The last deglaciation is an interval of marked changes in the climate system. The records of glaciation of tropical mountains offer unique opportunities to assess the timing of changes and the sensitivity of tropical climates to global and regional ...
L. Vázquez-Selem, M.S. Lachniet
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

New information on the Havelte Group site Ahrenshöft LA 58 D (Nordfriesland, Germany) - Preliminary results of the 2008 fieldwork [PDF]

, 2010
Late Glacial processes of human colonisation, adaptation and development represent a large field of study with a wide range of approaches. With respect to the archaeological succession from the classic Hamburgian to the Havelte Group, studies on the ...
Clausen, I., Housley, R. A., Miller, C. E., Riede, F., Usinger, H., Weber, M.-J.   +5 more
core  

Refining the interpretation of lacustrine carbonate isotope records: Implications of a mineralogy-specific Lake Van case study [PDF]

, 2019
Oxygen and carbon isotope (δ18O and δ13C) data from bulk carbonates are widely applied proxies for temperature, the precipitation/evaporation ratio and productivity in lacustrine palaeohydrology and palaeoclimatology. In case of the terminal and alkaline
Immenhauser, Adrian, Jöns, Niels, Kwiecien, Ola, McCormack, Jeremy, Nehrke, Gernot   +4 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source