Results 131 to 140 of about 178,775 (272)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee   +16 more
wiley   +1 more source

The Value of Experience: Lessons from a Study of Reenactment

open access: yesEXARC Journal, 2016
It is no secret that in many ways experimental archaeology overlaps with what has come to be called experiential archaeology, an interpretive and humanistic approach to the past.
Samantha Hartford
doaj  

Zur Konstruktion der ‚mörderischen Juden‘ im Reich um 1492

open access: yesÖsterreichische Zeitschrift für Geschichtswissenschaften
In October 1492, 27 Jews were burned at the stake near the small town of Sternberg, and all remaining Jewish inhabitants were expelled from the county of Mecklenburg on the north-eastern periphery of the Holy Roman Empire, because of an alleged case of ...
Kristin Skottki
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022
Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley   +1 more source

EXARC at the Times and Epochs Festival, Kolomenskoye Park, Moscow

open access: yesEXARC Journal, 2013
As an EXARC Board member, I attended the Times and Epochs Festival in Moscow from June 21-23, 2013 in the open-air museum Kolomenskoye Park. This year, an estimated 200,000 people attended the medieval themed festival where they were able to witness and ...
Bill Schindler
doaj  

An Analysis of Contemporary Sources to Uncover the Medieval Identity of the Drink Bochet

open access: yesEXARC Journal, 2020
When Le Ménagier de Paris (1393), a medieval household manual detailing a woman's proper behavior in marriage and running a household, was newly translated and republished as The Good Wife’s Guide: a Medieval Household Book by the Cornell University ...
Susan Verberg
doaj  

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