Latency Reversing Agents: Kick and Kill of HTLV-1? [PDF]
International Journal of Molecular Sciences, 2021 Human T-cell leukemia virus type 1 (HTLV-1), the cause of adult T-cell leukemia/lymphoma (ATLL), is a retrovirus, which integrates into the host genome and persistently infects CD4+ T-cells.
Andrea K. Kress +2 more
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Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]
PLoS Computational Biology, 2018 Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj +3 more sources
Optimal Control of an HIV Model with Gene Therapy and Latency Reversing Agents
Mathematical and Computational Applications, 2021 In this paper, we study the dynamics of HIV under gene therapy and latency reversing agents. While previous works modeled either the use of gene therapy or latency reversing agents, we consider the effects of a combination treatment strategy.
Zachary Abernathy +3 more
doaj +2 more sources
Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents. [PDF]
Journal of Infectious Diseases, 2017 Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection despite effective antiretroviral therapy (ART) can fuel rebound viremia after ART interruption and is a central obstacle to the cure of HIV infection ...
Nancie M Archin
exaly +4 more sources
Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy? [PDF]
Viruses, 2021 Rungroch Sungthong +2 more
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Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents. [PDF]
Noncoding RNA, 2023 Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency.
Li R +4 more
europepmc +2 more sources
Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency [PDF]
International Journal of Molecular Sciences, 2021 Margherita Doria, Daniela Angela Covino
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Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents. [PDF]
Antimicrobial Agents and Chemotherapy, 2020 Indra Sarabia +2 more
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G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells [PDF]
Cell Cycle, 2020 Stephen Dewhurst +2 more
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Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens [PDF]
Medicinal Research Reviews, 2020 Ivan Sadowski, Pargol Hashemi
exaly +2 more sources