Results 11 to 20 of about 5,637 (227)

Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]

PLoS Computational Biology, 2018
Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj   +2 more sources

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy? [PDF]

Viruses, 2021
Rungroch Sungthong, Thanarat Salahong, Schwartz Christian   +2 more
exaly   +2 more sources

Approaches to discover latency-reversing agents

Journal of Virus Eradication, 2015
doaj   +2 more sources

Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency [PDF]

International Journal of Molecular Sciences, 2021
Margherita Doria, Daniela Angela Covino
exaly   +2 more sources

Identification of a promising new class of latency reversing agents

Journal of Virus Eradication, 2017
A. Gramatica, W. Greene, R. Schwarzer, M. Montano, T. Packard, E. Herzig, Warner Greene   +6 more
doaj   +2 more sources

23 Understanding the effects of latency reversing agents on HIV RNA splicing: implications for latency reversal

Journal of Virus Eradication, 2016
T.M. Mota, G. Khoury, J.C. Jacobson, H.K. Lu, F. Wightman, d.e.r. Sluis, J.L. Anderson, P.U. Cameron, S.R. Lewin, D.F.J. Purcell, R.M. Van   +10 more
doaj   +2 more sources

Diversity of small molecule HIV‐1 latency reversing agents identified in low‐ and high‐throughput small molecule screens [PDF]

Medicinal Research Reviews, 2020
Ivan Sadowski, Pargol Hashemi
exaly   +2 more sources

G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells [PDF]

Cell Cycle, 2020
Stephen Dewhurst, Robert Bambara, Sanjay Maggirwar   +2 more
exaly   +2 more sources

Optimisation of Smac mimetics as HIV-1 latency reversing agents

Journal of Virus Eradication, 2019
L. Pache, P. Teriete, M.D. Marsden, A.M. Spivak, D. Heimann, A.J. Portillo, V. Planelles, J.A. Zack, N.D.P. Cosford, S.K. Chanda   +9 more
doaj   +2 more sources

Dual TLR2 and TLR7 agonists as HIV latency-reversing agents. [PDF]

JCI Insight, 2018
The presence of a reservoir of latently infected cells in HIV-infected patients is a major barrier towards finding a cure. One active cure strategy is to find latency-reversing agents that induce viral reactivation, thus leading to immune cell recognition and elimination of latently infected cells, known as the shock-and-kill ...
Macedo AB, Novis CL, De Assis CM, Sorensen ES, Moszczynski P, Huang SH, Ren Y, Spivak AM, Jones RB, Planelles V, Bosque A.   +10 more
europepmc   +4 more sources