Results 51 to 60 of about 340,687 (262)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Frontiers in ImmunologyAfter primary infection with varicella, varicella-zoster virus (VZV) establishes a latent state that precedes the clinical manifestation of herpes zoster.
Dong-Gyun Han
doaj +1 more source
Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
Frontiers in Microbiology, 2016 Herpesviruses establish a chronic infection in the host characterized by intervals of lytic replication, quiescent latency, and reactivation from latency.
Laurie T Krug +3 more
doaj +1 more source
Multi-CAP Assisted Intelligent Mobile Edge Computing Networks for Internet of Things
IEEE Access, 2020 In this paper, we investigate intelligent mobile edge computing networks (MEC) with multiple computational access points (CAPs) for Internet of Things (IoT), where the user with limited computational capability has some tasks to be computed with the help
Liming Chen +5 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Viruses(1) Background: Retinal degeneration develops upon caspase-12 activation in aged BALB/c mice following systemic neonatal infection. (2) Methods: MCMV or medium was injected intraperitoneally (i.p.) into caspase-12−/− and caspase-12+/+ mice (on BALB/c ...
Jinxian Xu +5 more
doaj +1 more source
HIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies
Viruses, 2014 The major obstacle towards HIV-1 eradication is the life-long persistence of the virus in reservoirs of latently infected cells. In these cells the proviral DNA is integrated in the host’s genome but it does not actively replicate, becoming invisible to ...
Angela Battistini, Marco Sgarbanti
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FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Frontiers in Oncology, 2014 Mycobacterium tuberculosis (M. tuberculosis) infections are uncommon in recipients of hematopoietic stem cell transplantation. These infections are 10 to 40 times commoner in recipients of stem cell transplantation than in the general population but they
Khalid Ahmed Al-Anazi +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source