Results 51 to 60 of about 570,061 (302)

Dynamic Load Balancing for Enhanced Network Performance in IoT-Enabled Smart Healthcare With Fog Computing

open access: yesIEEE Access
The rapid expansion of Internet of Things (IoT) devices in healthcare has increased data volumes, creating challenges for the efficiency and latency of real-time monitoring systems.
Mohammed Alaa Ala'anzy   +4 more
doaj   +1 more source

Bioactive molecules released from cells infected with the Human Cytomegalovirus

open access: yesFrontiers in Microbiology, 2016
Following primary infection in humans, the Human Cytomegalovirus (HCMV) persists in a latent state throughout the host’s lifetime despite a strong and efficient immune response.
Anna eLuganini   +2 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants

open access: yesCell Reports, 2017
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine the distribution of latent replication-competent HIV-1 within ...
Bonnie Hiener   +18 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Strategic latency with temporal mutualism: a coevolutionary model of the host–varicella-zoster virus relationship

open access: yesFrontiers in Immunology
After primary infection with varicella, varicella-zoster virus (VZV) establishes a latent state that precedes the clinical manifestation of herpes zoster.
Dong-Gyun Han
doaj   +1 more source

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host

open access: yesFrontiers in Microbiology, 2016
Herpesviruses establish a chronic infection in the host characterized by intervals of lytic replication, quiescent latency, and reactivation from latency.
Laurie T Krug   +3 more
doaj   +1 more source

Multi-CAP Assisted Intelligent Mobile Edge Computing Networks for Internet of Things

open access: yesIEEE Access, 2020
In this paper, we investigate intelligent mobile edge computing networks (MEC) with multiple computational access points (CAPs) for Internet of Things (IoT), where the user with limited computational capability has some tasks to be computed with the help
Liming Chen   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Control of gammaherpesvirus latency by latent antigen-specific CD8(+) T cells [PDF]

open access: yes, 2000
The contribution of the latent antigen-specific CD8(+) T cell response to the control of gammaherpesvirus latency is currently obscure. Some latent antigens induce potent T cell responses, but little is known about their induction or the role they play ...
Blackman, M A   +7 more
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