Results 51 to 60 of about 475,024 (262)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Malaria attributable fractions with changing transmission intensity: Bayesian latent class vs logistic models

Malaria Journal, 2022
Background Asymptomatic carriage of malaria parasites is common in high transmission intensity areas and confounds clinical case definitions for research studies.
Kennedy Mwai, Irene Nkumama, Amos Thairu, James Mburu, Dennis Odera, Rinter Kimathi, Lydia Nyamako, James Tuju, Samson Kinyanjui, Eustasius Musenge, Faith Osier   +10 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Measuring the performance of LPA, LCGA, LGCM, and GMM in identifying the homogenous subgroups (latent classes) within the wider heterogeneous population of patients on DTG

Frontiers in Applied Mathematics and Statistics
BackgroundIdentifying heterogeneity in longitudinal data is critical for understanding diverse trajectories in clinical and epidemiological research. Traditional analytical methods often fail to distinguish latent subpopulations.
Harrid Nkhoma, Atupele Ngina Mulaga, Save Kumwenda, Mphatso Kamndaya   +3 more
doaj   +1 more source

Revisiting the hypothesis of syndromic frailty: a cross-sectional study of the structural validity of the frailty phenotype

BMC Geriatrics, 2020
Background Fried’s Phenotype Model of Frailty (PMF) postulates that frailty is a syndrome. Features of a syndrome are a heterogeneous population that can be split into at least two classes, those presenting and those not presenting the syndrome ...
François Béland, Dominic Julien, Christina Wolfson, Howard Bergman, Pierrette Gaudreau, Claude Galand, John Fletcher, Maria-Victoria Zunzunegui, Bryna Shatenstein, Marie-Jeanne Kergoat, José A. Morais, Tamàs Fülöp   +11 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

poLCA: An R Package for Polytomous Variable Latent Class Analysis

Journal of Statistical Software, 2011
poLCA is a software package for the estimation of latent class and latent class regression models for polytomous outcome variables, implemented in the R statistical computing environment. Both models can be called using a single simple command line.
Drew A. Linzer, Jeffrey B. Lewis
doaj  

The association between leisure activity patterns and the prevalence of mild cognitive impairment in community-dwelling older adults

Frontiers in Psychology, 2023
ObjectivesThe study aimed to identify leisure activity patterns among older adults and explore the differences in the prevalence of mild cognitive impairment (MCI) of these patterns.MethodsA total of 352 older adults aged ≥ 65 years in Shijiazhuang were ...
Yuanyuan Zhang, Yuanyuan Zhang, Yuanyuan Zhang, Xinxin Yang, Xinxin Yang, Xinxin Yang, Linlin Guo, Linlin Guo, Linlin Guo, Xinyi Xu, Bingyu Chen, Bingyu Chen, Bingyu Chen, Xiaowei Ma, Xiaowei Ma, Yan Li, Yan Li, Yan Li   +17 more
doaj   +1 more source

Latent class models for classification [PDF]

Computational Statistics & Data Analysis, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Vermunt, J.K., Magidson, J.
openaire   +2 more sources

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source