Results 61 to 70 of about 853,014 (261)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Frontiers in Psychology, 2022 This study aimed to explore the latent profiles across perceived parental marital conflict and family cohesion, as well as the transition patterns within-person and within-sample profiles over time.
Tingting Gao +14 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Emotional Labor and Occupational Well-Being: Latent Profile Transition Analysis Approach
Frontiers in Psychology, 2018 This study used the latent profile transition analysis (LPTA) to analyze whether emotional labor profiles change across time and how these profiles relate to occupational well-being (i.e., job satisfaction, quality of work life, psychological distress ...
Francis Cheung +2 more
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Patterns of Substance Use Across the First Year of College and Associated Risk Factors
Frontiers in Psychiatry, 2015 Starting college is a major life transition. This study aims to characterize patterns of substance use across a variety of substances across the first year of college and identify associated factors.
Seung Bin eCho +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Emotion regulation profiles across time: a latent transition analysis
International Journal of Adolescence and YouthDifficulties in emotion regulation are associated with mental health problems during adolescence. This study aimed to identify distinct emotion regulation profiles in adolescents, examine potential differences between profiles, and examine transitions ...
Hedvig Andersson +5 more
doaj +1 more source
Predictors and Changes in Paternal Perinatal Depression Profiles—Insights From the DREAM Study
Frontiers in Psychiatry, 2020 In contrast to the large body of research on maternal perinatal depression, paternal perinatal mental health has received little attention; and longitudinal studies on paternal perinatal depression, following (expectant) fathers over time, are ...
Susan Garthus-Niegel +7 more
doaj +1 more source
Bouncing back from COVID-19: a Western Australian community perspective
Frontiers in Public Health, 2023 IntroductionThis study explored the behavioral profiles of residing Western Australians during a COVID-19 lockdown period and transitions in behavior post-lockdown.MethodsA total of 313 participants (76% female, age: M = 50.1, SD = 15.7 years) completed ...
Kiira Karoliina Sarasjärvi +5 more
doaj +1 more source