Results 101 to 110 of about 2,066,293 (256)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Self-study modules on tuberculosis 1-5 : Introduction [PDF]

Course #WB2556The Self-Study Modules on Tuberculosis is a series of educational modules designed to provide information about tuberculosis (TB) in a self-study format. The series consists of nine modules that are separated into two parts. The first part,

core   +3 more sources

Preventive therapy for latent tuberculosis infection-the promise and the challenges.

International Journal of Infectious Diseases, 2017
Around one third of the world's population may harbour latent tuberculosis infection (LTBI), an asymptomatic immunological state that confers a heightened risk of subsequently developing tuberculosis (TB).
G. Fox, C. Dobler, B. Marais, J. Denholm
semanticscholar   +1 more source

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis–infected individuals [PDF]

, 2009
Copyright © 2009 by the American Thoracic Society.Rationale: An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care.
Beveridge, NER, Alder, N, Minassian, A, Gleeson, FV, Pasvol, G, Hill, AVS, Davies, RJO, Van Wijgerden, J, Poulton, I, Sander, CR, Pathan, AA, McShane, H   +11 more
core   +1 more source

Toxoplasma gondii Infection After Kidney Transplantation: A Case Report and Literature Review

Organ Medicine, EarlyView.
Toxoplasma gondii infection after kidney transplantation is rare and presents with nonspecific clinical manifestations; however, the associated mortality rate is high. We discuss the relevant literature, clinical manifestations, therapeutic regimens, and prognoses of post‐transplantation toxoplasmosis.
Peng Zhang, Xingqiang Lai, Rongxin Chen, Li Li, Jiali Fang, Guanghui Li, Junjie Ma, Luhao Liu, Zheng Chen   +8 more
wiley   +1 more source

Incidence and risk factors for tuberculosis in people living with HIV: cohort from HIV referral health centers in Recife, Brazil. [PDF]

PLoS ONE, 2013
OBJECTIVE: To identify the incidence of and risk factors for tuberculosis in people living with HIV (PLHIV). DESIGN: Observational, prospective cohort study. METHODS: A total of 2069 HIV-infected patients was observed between July 2007 and December 2010.
Joanna d'Arc Lyra Batista, Maria de Fátima Pessoa Militão de Albuquerque, Magda Maruza, Ricardo Arraes de Alencar Ximenes, Marcela Lopes Santos, Ulisses Ramos Montarroyos, Demócrito de Barros Miranda-Filho, Heloisa Ramos Lacerda, Laura Cunha Rodrigues   +8 more
doaj   +1 more source

Self-administered Versus Directly Observed Once-Weekly Isoniazid and Rifapentine Treatment of Latent Tuberculosis Infection

Annals of Internal Medicine, 2017
Background: Expanding latent tuberculosis treatment is important to decrease active disease globally. Once-weekly isoniazid and rifapentine for 12 doses is effective but limited by requiring direct observation.
R. Belknap, David P. Holland, Pei-Jean I. Feng, J. Millet, J. Caylà, N. Martinson, A. Wright, Michael P. Chen, R. Moro, N. Scott, Bert Arevalo, J. Miro, M. Villarino, M. Weiner, A. Borisov   +14 more
semanticscholar   +1 more source

Transcription of Genes Involved in Sulfolipid and Polyacyltrehalose Biosynthesis of Mycobacterium tuberculosis in Experimental Latent Tuberculosis Infection [PDF]

, 2013
he Influence of trehalose-based glycolipids in the virulence of Mycobacterium tuberculosis (Mtb) is recognised; however, the actual role of these cell-wall glycolipids in latent infection is unknown.
Soto, Carlos Y., Hernández-Pando, Rogelio, Helguera-Repetto, Cecilia, Laura P. Salas (385707), Jimmy E Rodríguez, Gonzalez y Merchand, Jorge, Jimmy E. Rodríguez (385705), Ana S Ramírez, Carlos Y. Soto (385710), Rodríguez, Jimmy E., Jorge Gonzalez-y-Merchand, Salas, Laura P., Carlos Y Soto, Ramírez, Ana S., Jorge Gonzalez-y-Merchand (385709), Cecilia Helguera-Repetto, Cecilia Helguera-Repetto (385708), Rogelio Hernández-Pando (60614), Laura P Salas, Rogelio Hernández-Pando, Ana S. Ramírez (385706)   +20 more
core   +2 more sources

Multimodal artificial intelligence in medical biotechnology: Integrating genomics, imaging, and clinical data for precision therapeutics

Precision Medical Sciences, EarlyView.
Overview of multimodal artificial intelligence (AI) for precision therapeutics. Diverse biomedical data modalities, including multi‐omics, medical imaging, digital pathology, electronic health records, wearable‐device data, and molecular information, are integrated through multimodal AI frameworks incorporating fusion strategies, foundation models ...
Gedion Mengistu Dejen
wiley   +1 more source

Ethical evaluation of immigration screening policy for latent tuberculosis infection

Australian and New Zealand Journal of Public Health, 2012
Objective : In Australia and New Zealand, immigration screening policy relating to tuberculosis is targeted towards identifying potential new arrivals with active infectious pulmonary disease.
Justin T. Denholm, Emma S. McBryde, Graham V. Brown   +2 more
doaj   +1 more source