Results 111 to 120 of about 54,559 (220)
Background: Tuberculosis remains a major global public health challenge. This study determined the prevalence of latent tuberculosis infection (LTBI) using the Interferon-Gamma Release Assay (IGRA) and identified associated risk factors among
Sakaren Lawong
doaj +1 more source
ABSTRACT Background and Aims Integrating services for diseases appears to improve healthcare access and outcomes. This scoping review aimed to evaluate how different countries implement the integration of HIV, viral hepatitis, and sexually transmitted infection (STI) services.
Parya Jangipour Afshar +7 more
wiley +1 more source
Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review
This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz +10 more
wiley +1 more source
In NSCLC patients with solitary distant metastasis (SDM), early local treatment significantly delays the progression to multi‐metastasis by 14 months (HR = 0.55) compared to delayed or no treatment. This multicenter cohort study highlights SDM as an indolent state, emphasizing the critical time window for effective local intervention. .
Kang Miao +10 more
wiley +1 more source
Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi +6 more
wiley +1 more source
Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao +10 more
wiley +1 more source
Abstract In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on specialized factors known as helicase loaders. The DciA family of helicase
Daniele Mazzoletti +8 more
wiley +1 more source
Can Multidrug‐Resistant and Extensively Drug‐Resistant Tuberculosis be Treated More Successfully?
Drug‐resistant cases of tuberculosis are increasing, complicating treatment strategies. Prior to the development of pharmacological agents, improving patient health at institutions called ‘sanatoria’ was a successful primary treatment. World Health Organization data combined with information from historical reports estimate that current treatments can ...
K. L. Holloway‐Kew, M. Henneberg
wiley +1 more source
Latent Adolescent Pulmonary Tuberculosis [PDF]
R C, Wingfield, A M, Macpherson
openaire +2 more sources

