Results 131 to 140 of about 3,405 (181)

Variance‐Guided Regression for Heteroscedastic Data With a Grouping‐Based Extension for Nonlinear Prediction

Statistics in Medicine, Volume 45, Issue 13-14, June 2026.
ABSTRACT Although homoscedasticity is often assumed in linear regression, real data may show variance patterns or residual structures that violate this assumption. We propose VarGuid, a variance‐guided framework for two related settings: Covariate‐dependent conditional variance under a global linear mean model, and residual nonlinear mean structure ...
Sibei Liu, Min Lu
wiley   +1 more source

The Relationship Between Pulmonary Spiculation and Central Fibrosis, Along With Other Clinicopathological Features, in Invasive Lung Adenocarcinoma and Its Prognostic Significance

Thoracic Cancer, Volume 17, Issue 11, June 2026.
Although spiculation in IAC reflects tumor aggressiveness, its prognostic value is associated with central fibrosis subtypes. Spiculation driven by collagenous hyperplasia correlates with poorer outcomes, whereas spiculation associated with extensive alveolar collapse serves as a protective factor.
Hanbo Le, Yongkui Zhang, Heping Wang, Yuanyuan Wen, Liyong Qian, Hui He   +5 more
wiley   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Inconsistent standard of care for tuberculosis screening and preventive therapy before initiating systemic psoriasis treatment

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 737-744, June 2026.
Summary Background and Objectives Preventive tuberculosis (TB) therapy before initiating MTX or IL‐17/IL‐23/IL‐12/23p40 inhibitors for latent tuberculosis infection (LTBI) is supported by indirect evidence of TB reactivations with TNF inhibitors. However, direct evidence for MTX or IL‐17/IL‐23/IL‐12/23p40 inhibitors is limited.
Christoph Zeyen, Ruben Heuer, Brit Haecker, Tom Schaberg, Alexander Nast   +4 more
wiley   +1 more source

Uneinheitliche Standards beim Tuberkulose‐Screening und der präventiven Tuberkulosetherapie vor Beginn einer systemischen Psoriasistherapie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 737-745, June 2026.
Zusammenfassung Hintergrund und Ziele Die präventive Therapie einer Tuberkulose (TB) vor der Einleitung von Methotrexat (MTX) oder IL‐17/IL‐23/IL‐12/23p40‐Inhibitoren bei latenter Tuberkuloseinfektion (LTBI) wird indirekt durch ein nachweislich erhöhtes TB‐Reaktivierungsrisiko unter TNF‐Inhibitoren gestützt.
Christoph Zeyen, Ruben Heuer, Brit Haecker, Tom Schaberg, Alexander Nast   +4 more
wiley   +1 more source

Latent Neoehrlichia mikurensis Infections May Be Reactivated in Patients With B‐Cell Lymphomas Treated With Rituximab

Immunology, Volume 178, Issue 2, Page 307-317, June 2026.
Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Linda Wass, Catharina Lewerin, Daniel Jaén‐Luchoro, Christine Lingblom, Christine Wennerås   +4 more
wiley   +1 more source

Decoding the Oncogenic Role of GNG10 in Colorectal Cancer: A Non‐Canonical Wnt Pathway–Driven Mechanism

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Guanine nucleotide‐binding protein gamma 10 (GNG10) is implicated in various biological processes, yet its specific oncogenic role in colorectal cancer (CRC) remains poorly defined. This study aimed to elucidate the expression patterns, biological functions, and underlying mechanisms of GNG10 in CRC progression.
Xitao Zhang, Yuting Tang, Xuexiao Li, Ou Li, Yaoqian Liu, Jianping He, Tianlai Liu   +6 more
wiley   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 963-979, June 2026.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault, Emilie Brenaut, Marie‐Emeline Marniquet, Carla Berthault, Lea Canoen, Clarisse Marcombes, Audrey Melin, Raphaël Ouakrat, Julie Charles, Stephane Mouret, Olivier Potie, Laetitia Penso, Laura Pina Vegas, Guillaume Larid, Marine Roux, Colombe Bougeard, Sandy Sylvain, Clara Labonne, Tania Randriamiarana, Da Hee Pitaud, Floriane Etheve, Jeremy Gottlieb, Laurie Gouillon, Marine Chastagner, Emilie Sbidian, Hélène Aubert, on behalf of the Psoriasis Research Group of the French Society of Dermatology (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), Hélène Aubert, Marie Masson Regnault, Emilie Brenaut, Emilie Sbidian, Laura Pina Vegas, Laetitia Penso, Jeremy Gottlieb, Marine Roux, Clara Labonne, Tania Randriamiarana, Floriane Etheve, Da Hee Pitaud, Marie‐Emeline Marniquet, Carla Berthault, Clarisse Marcombes, Audrey Melin, Colombe Bougeard, Julie Charles, Olivier Potie, Léa Canoen, Laurie Gouillon, Marine Chastagner, Sandy Sylvain, Guillaume Larid, Raphaël Ouakrat   +51 more
wiley   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in ESADA

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
ABSTRACT Excessive daytime sleepiness (EDS) as well as insomnia have been associated with a higher risk for cardiovascular disease in patients with obstructive sleep apnoea (OSA). The link is not fully understood but may involve dyslipidaemia. The aim of the study was to analyse if the EDS and insomnia phenotypes were associated with deranged serum ...
Andras Bikov, Sebastien Bailly, Ulla Anttalainen, Tarja Saaresranta, Ozen K. Basoglu, Sophia Schiza, Izolde Bouloukaki, Pawel Sliwinski, Athanasia Pataka, Dries Testelmans, Francesco Fanfulla, Haralampos Gouveris, Ludger Grote, Stefan Mihaicuta, the ESADA collaborators, P. Steiropoulos, J. Verbraecken, E. Petiet, Georgia Trakada, I. Fietze, T. Penzel, Ondrej Ludka, I. Bouloukaki, S. Schiza, W. T. McNicholas, S. Ryan, R. L. Riha, J. A. Kvamme, L. Grote, J. Hedner, D. Zou, Katrien Hertegonne, Dirk Pevernagie, S. Bailly, J. L. Pépin, R. Tamisier, H. Hein, O. K. Basoglu, M. S. Tasbakan, P. Joppa, R. Staats, Dries Testelmans, Alexandros Kalkanis, Haralampos Gouveris, K. Ludwig, C. Lombardi, G. Parati, M. R. Bonsignore, Francesco Fanfulla, M. Petitjean, G. Roisman, M. Drummond, M. van Zeller, W. Randerath, S. Mathes, Z. Dogas, T. Galic, A. Pataka, S. Mihaicuta, U. Anttalainen, T. Saaresranta, P. Sliwinski   +61 more
wiley   +1 more source