Results 131 to 140 of about 53,392 (269)

Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)

Diabetic Medicine, Volume 43, Issue 7, July 2026.
Abstract Introduction In 2025, the Medicines and Healthcare products Regulatory Agency (MHRA) approved the use of teplizumab (a monoclonal anti‐CD3 antibody) to delay progression from Stage 2 to Stage 3 Type 1 diabetes in the UK. Methods To address the need for clear guidance on managing patients eligible for teplizumab therapy, the British Society of ...
Renuka P. Dias, M. Loredana Marcovecchio, Ruben H. Willemsen, Fiona Campbell, Ahmad Ashour, Philip Newland‐Jones, Jennifer Cooper, Parth Narendran, Neil P. Wright   +8 more
wiley   +1 more source

Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

, 2010
Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is ...
Gideon, Hannah Priyadarshini
core  

Diagnostic accuracy study of STANDARD TB-Feron FIA and STANDARD TB-Feron ELISA tests for tuberculosis infection diagnosis in Eastern European setting

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Introduction: Tuberculosis infection (TBI) is diagnosed based on a positive immune response to M. tuberculosis antigens. This study aimed to evaluate both the qualitative and quantitative performance of two novel IGRA-based tests, the STANDARD E TB-Feron
Valeriu Crudu, Dumitru Chesov, Alexandru Codreanu, Nadejda Turcanu, Nelly Ciobanu, Liuba Nepoliuc, Doina Rusu   +6 more
doaj   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, Volume 178, Issue 3, Page 417-427, July 2026.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Accurate diagnosis of latent tuberculosis in children, people who are immunocompromised or at risk from immunosuppression and recent arrivals from countries with a high incidence of tuberculosis: systematic review and economic evaluation

, 2016
Background - Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world’s population is infected with MTB; TB has an annual incidence of
Seedat, Farah, Court, Rachel, Madan, Jason, Ngianga-Bakwin Kandala, Clare Walker, Tara Gurung, Gurung, Tara, Kandala, Ngianga-Bakwin, Sutcliffe, P. (Paul), Sian Taylor-Phillips, Aileen Clarke, Auguste, Peter, Jason Madan, Tsertsvadze, Alexander, Pink, Joshua, Rachel Court, Joshua Pink, Courtney, Rachel, Peter Auguste, Sutcliffe, Paul, Alexander Tsertsvadze, Court, Rachel A., Paul Sutcliffe, Karoline Freeman, Freeman, Karoline, Farah Seedat, Walker, Clare, Taylor-Phillips, Sian, Clarke, Aileen   +28 more
core   +1 more source

Factors Associated with Pulmonary Tuberculosis and Latent Tuberculosis Infection of Household Contacts with Drug-Sensitive Tuberculosis Patients in Medan

Public Health of Indonesia
Background: Latent Tuberculosis Infection (LTBI) has the potential to develop into active TB. Therefore, appropriate diagnosis and management are essential, especially in high-risk populations such as individuals who are in household contact with active
Rina Sundari, Bintang Yinke Magdalena Sinaga, Delores Elisabeth Sormin, Arlinda Sari Wahyuni   +3 more
doaj   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX.

, 2009
The macrophage is the natural niche of Mycobacterium tuberculosis infection. In order to combat oxidative and nitrosative stresses and persist in macrophages successfully, M. tuberculosis is endowed with a very efficient antioxidant complex.
Hu, Y, Yanmin Hu, Anthony R M Coates, Anthony R. M. Coates, Coates, AR   +4 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Effect of HIV-1 infection on T-Cell-based and skin test detection of tuberculosis infection

, 2007
RATIONALE: Two forms of the IFN-gamma release assay (IFNGRA) to detect tuberculosis infection are available, but neither has been evaluated in comparable HIV-infected and uninfected persons in a high tuberculosis incidence environment.
Connell, Tom G, Maartens, Gary, Mouton, Priscilla, Wilkinson, K A, Rangaka, Molebogeng Xheeda, Van Cutsem, Gilles, Morroni, Chelsea, Diwakar, Lavanya; id_orcid, Mouton, P, Seldon, R, Wilkinson, Robert J, Morroni, C, Seldon, Ronnett, Connell, T G, Wilkinson, R J, Meintjes, Graeme Ayton, Rangaka, M X, Diwakar, L, Van Cutsem, G, Maartens, G, Wilkinson, Katalin A, Diwakar, Lavanya, Meintjes, G A   +22 more
core   +1 more source