Tuberculosis and COVID-19 Dually Affect Human Th17 Cell Immune Response
Biomedicines, 2023 COVID-19 infection not only profoundly impacts the detection of tuberculosis infection (Tbc) but also affects modality in tuberculosis patient immune response.
Anna Starshinova +5 more
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The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition [PDF]
, 2016 M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding
Barry III, CE +5 more
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Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities [PDF]
, 2012 Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary
Alexandre Harari +118 more
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PLoS ONE, 2021 One principle of tuberculosis control is to prevent the development of tuberculosis disease by treating individuals with latent tuberculosis infection.
Henok G Woldu +7 more
doaj +1 more source
Latent Tuberculosis Infection [PDF]
European Respiratory & Pulmonary Diseases, 2018 Tuberculosis (TB) is a major global public health problem and is the leading cause of death linked to a single pathogen, ranking above human immunodeficiency virus (HIV).1 Clinically, TB has been categorised as active disease (patients who are generally symptomatic and may be infectious if pulmonary involvement is present) and latent infection ...
openaire +1 more source
PLoS ONE, 2017 BackgroundThe majority of tuberculosis in migrants to Canada occurs due to reactivation of latent TB infection. Risk of tuberculosis in those with latent tuberculosis infection can be significantly reduced with treatment.
Jonathon R Campbell +5 more
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Outlook for tuberculosis elimination in California: An individual-based stochastic model. [PDF]
, 2019 RationaleAs part of the End TB Strategy, the World Health Organization calls for low-tuberculosis (TB) incidence settings to achieve pre-elimination (<10 cases per million) and elimination (<1 case per million) by 2035 and 2050, respectively. These
Barry, Pennan M +10 more
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Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection. [PDF]
PLoS ONE, 2009 CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with active tuberculosis disease.
Nadia Caccamo +14 more
doaj +1 more source
New approaches in the diagnosis and treatment of latent tuberculosis infection [PDF]
, 2010 With nearly 9 million new active disease cases and 2 million deaths occurring worldwide every year, tuberculosis continues to remain a major public health problem. Exposure to Mycobacterium tuberculosis leads to active disease in only ~10% people.
Suhail Ahmad
core +1 more source
Serum proteomics of active tuberculosis patients and contacts reveals unique processes activated during Mycobacterium tuberculosis infection. [PDF]
, 2020 Tuberculosis (TB) is the most lethal infection among infectious diseases. The specific aim of this study was to establish panels of serum protein biomarkers representative of active TB patients and their household contacts who were either infected (LTBI)
Anibarro, L +11 more
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