Results 21 to 30 of about 2,280,070 (229)

Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans [PDF]

, 2014
Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed ...
Vic L Arcus, Noel Karalus (533380), Coley, Kathy, Marchiano, Emily, David Alland, Karalus, Noel, Shannon D. Manning (148732), Ray T Cursons, Manning, Shannon D., Ray T. Cursons (533378), David Alland (31640), Alland, David, Noel Karalus, Emily Marchiano, Roberto Colangeli, Kathy Coley, Cursons, Raymond T., Emily Marchiano (533383), Vic L. Arcus (533377), Roberto Colangeli (31628), Soyeon Kim (533382), Colangeli, Roberto, Ali Ruthe (533379), Ruthe, Ali, Ali Ruthe, Kathy Coley (533381), Soyeon Kim, Arcus, Vickery L., Shannon D Manning, Kim, Soyeon, Cursons Ray T., Kim Soyeon, Manning Shannon D., Alland David, Arcus Vic L., Coley Kathy, Colangeli Roberto, Karalus Noel, Ruthe Ali, Marchiano Emily   +39 more
core   +2 more sources

Tuberculosis and COVID-19 Dually Affect Human Th17 Cell Immune Response

Biomedicines, 2023
COVID-19 infection not only profoundly impacts the detection of tuberculosis infection (Tbc) but also affects modality in tuberculosis patient immune response.
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Anna Malkova, Irina Dovgaluk, Dmitry Kudlay   +5 more
doaj   +1 more source

Cost-effectiveness of post-landing latent tuberculosis infection control strategies in new migrants to Canada.

PLoS ONE, 2017
BackgroundThe majority of tuberculosis in migrants to Canada occurs due to reactivation of latent TB infection. Risk of tuberculosis in those with latent tuberculosis infection can be significantly reduced with treatment.
Jonathon R Campbell, James C Johnston, Mohsen Sadatsafavi, Victoria J Cook, R Kevin Elwood, Fawziah Marra   +5 more
doaj   +1 more source

Determining Mycobacterium tuberculosis infection among BCG-immunised Ugandan children by T-SPOT.TB and tuberculin skin testing. [PDF]

, 2012
BACKGROUND: Children with latent tuberculosis infection (LTBI) represent a huge reservoir for future disease. We wished to determine Mycobacterium tuberculosis (M.tb) infection prevalence among BCG-immunised five-year-old children in Entebbe, Uganda, but
Webb, Emily L, Gyaviira Nkurunungi, Muhangi Lawrence, Cose Stephen, Joseph R Fitchett, Akurut, Hellen, Elliott Alison M., Kizito Dennison, Kizindo Robert, Muhangi, Lawrence, Swaib A Lule, Lawrence Muhangi, Alison M Elliott, Akurut Hellen, Hellen Akurut, Robert Kizindo, Sebina, Ismail, Cose, Stephen, Elliott, Alison M, Nkurunungi Gyaviira, Kizito, Dennison, Fitchett, Joseph R, Sebina Ismail, Kizindo, Robert, Emily L Webb, Webb Emily L., Lutangira Jimreeves E., Jimreeves E Lutangira, Lule Swaib A., Stephen Cose, Lule, Swaib A, Dennison Kizito, Fitchett Joseph R., Nkurunungi, Gyaviira, Lutangira, Jimreeves E, Ismail Sebina   +35 more
core   +1 more source

Defining an intermediate category of tuberculin skin test: A mixture model analysis of two high-risk populations from Kampala, Uganda.

PLoS ONE, 2021
One principle of tuberculosis control is to prevent the development of tuberculosis disease by treating individuals with latent tuberculosis infection.
Henok G Woldu, Sarah Zalwango, Leonardo Martinez, María Eugenia Castellanos, Robert Kakaire, Juliet N Sekandi, Noah Kiwanuka, Christopher C Whalen   +7 more
doaj   +1 more source

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Tuberculosis State Is Associated with Expression of Toll-Like Receptor 2 in Sputum Macrophages

mSphere, 2017
During tuberculosis, macrophages are critical for both pathogen survival and host immune activation. Since expression of particular cell surface markers reflects cell function, we used flow cytometry to measure the abundance of surface markers associated
Karim Lakehal, David Levine, Kathleen F. Kerr, Pooja Vir, Natalie Bruiners, Alfred Lardizabal, Maria Laura Gennaro, Richard Pine   +7 more
doaj   +1 more source

Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection. [PDF]

PLoS ONE, 2009
CD8 T-cells contribute to control of Mycobacterium tuberculosis infection, but little is known about the quality of the CD8 T-cell response in subjects with latent infection and in patients with active tuberculosis disease.
Nadia Caccamo, Giuliana Guggino, Serena Meraviglia, Giuseppe Gelsomino, Paola Di Carlo, Lucina Titone, Marialuisa Bocchino, Domenico Galati, Alessandro Matarese, Jan Nouta, Michel R Klein, Alfredo Salerno, Alessandro Sanduzzi, Francesco Dieli, Tom H M Ottenhoff   +14 more
doaj   +1 more source

Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection [PDF]

, 2011
The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T ...
Moshi, Noell Dominika
core   +1 more source

Tuberculosis Infection and Latent Tuberculosis

Tuberculosis and Respiratory Diseases, 2016
Active tuberculosis (TB) has a greater burden of TB bacilli than latent TB and acts as an infection source for contacts. Latent tuberculosis infection (LTBI) is the state in which humans are infected with Mycobacterium tuberculosis without any clinical symptoms, radiological abnormality, or microbiological evidence.
openaire   +2 more sources