Results 41 to 50 of about 53,392 (269)

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Whole genome sequencing of Mycobacterium tuberculosis reveals slow growth and low mutation rates during latent infections in humans

, 2014
Very little is known about the growth and mutation rates of Mycobacterium tuberculosis during latent infection in humans. However, studies in rhesus macaques have suggested that latent infections have mutation rates that are higher than that observed ...
Vic L Arcus, Noel Karalus (533380), Coley, Kathy, Marchiano, Emily, David Alland, Karalus, Noel, Shannon D. Manning (148732), Ray T Cursons, Manning, Shannon D., Ray T. Cursons (533378), David Alland (31640), Alland, David, Noel Karalus, Emily Marchiano, Roberto Colangeli, Kathy Coley, Cursons, Raymond T., Emily Marchiano (533383), Vic L. Arcus (533377), Roberto Colangeli (31628), Soyeon Kim (533382), Colangeli, Roberto, Ali Ruthe (533379), Ruthe, Ali, Ali Ruthe, Kathy Coley (533381), Soyeon Kim, Arcus, Vickery L., Shannon D Manning, Kim, Soyeon   +29 more
core   +1 more source

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis–infected individuals [PDF]

, 2009
Copyright © 2009 by the American Thoracic Society.Rationale: An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care.
Beveridge, NER, Alder, N, Davies, RJ, Minassian, A, Hill, Adrian, Beveridge, NE, Gleeson, FV, Pasvol, G, Hill, AVS, Mcshane, Helen, Davies, RJO, Van Wijgerden, J, Gleeson, Fergus, Poulton, I, Sander, CR, Pathan, AA, McShane, H, Hill, AV   +17 more
core   +1 more source

Immunological assays in the diagnosis of tuberculosis infection at the beginning of 21st century [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
A subject infected by tubercle bacilli may immediately develop the disease (primary tuberculosis), witch occurs in a few number of infected persons, or may overcome the primary infection (a latent carrier of the infection).
Kašiković-Lečić Svetlana, Pavlović Slobodan, Kuruc Vesna, Ilić Miroslav   +3 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Tuberculosis contact tracing among children and adolescent referred to children's hospital in Rio de Janeiro, Brazil

Brazilian Journal of Infectious Diseases, 2015
Objective: To describe the investigation of latent tuberculosis infection and indication for isoniazid preventive therapy in children and adolescents evaluated at the children's hospital. Methods: This retrospective study examines all latent tuberculosis
Angela Marcia Cabral Mendonça, Afrânio Lineu Kritski, Clemax Couto Sant’Anna   +2 more
doaj   +1 more source

Gene expression in peripheral blood cells for differentiation of active and latent tuberculosis infection in children and adolescents

Туберкулез и болезни лёгких, 2020
The objective: to analyze the expression of certain genes in the blood cells of children and adolescence to differentiate the active and latent phases of tuberculosis infection.Subjects and methods.
A. A. Elov, M. A. Vladimirskiy, S. V. Smerdin, O. I. Elufimova   +3 more
doaj   +1 more source

Managing latent tuberculosis infection and tuberculosis in children

Pulmonology, 2018
Tuberculosis (TB) is a major cause of childhood morbidity and mortality worldwide. The aim of this review is to describe the management of the child with TB and latent tuberculosis infection (LTBI). To develop this article, a working group reviewed relevant epidemiological and other scientific studies and established practices in conducting LBTI and TB
I. Carvalho, D. Goletti, S. Manga, D.R. Silva, D. Manissero, G. Migliori   +5 more
openaire   +4 more sources

Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo. [PDF]

, 2011
The level of bacterial activity is only poorly defined during asymptomatic Mycobacterium tuberculosis (MTB) infection. The objective was to study the capacity of a new biomarker, the expression of the T cell maturation marker CD27 on MTB-specific CD4 T ...
Geldmacher Christof, Leonard Maboko, Koup Richard A., Andrea Rachow, Njabulo Ngwenyama, Hoelscher, Michael, Rachow, Andrea, Geldmacher, Christof, Klaus Reither, Michael Hoelscher, Koup, Richard A., Schuetz, Alexandra, Hoelscher Michael, Haule, Antelmo, Koup, Richard A, Ngwenyama, Njabulo, Antelmo Haule, Reither, Klaus, Alexandra Schuetz, Richard A. Koup, Haule Antelmo, Andreas Meyerhans, Schuetz Alexandra, Christof Geldmacher, Maboko Leonard, Rachow Andrea, Reither Klaus, Meyerhans Andreas, Maboko, Leonard, Richard A Koup, Ngwenyama Njabulo, Meyerhans, Andreas   +31 more
core   +1 more source

Association between hematological inflammatory markers and latent TB infection: insights from NHANES 2011–2012 and transcriptomic data

Frontiers in Cellular and Infection Microbiology
BackgroundLatent tuberculosis infection affects about one-quarter of the global population and can progress to active tuberculosis. Hematological inflammatory markers, such as the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio ...
Yang Liu, Chunyan He, He Zhao, Weiyao Zhong, Shihua Sun, Zhuo Li, Jingwei Shi   +6 more
doaj   +1 more source