Results 71 to 80 of about 88,192 (248)

Latent Tuberculosis Infection - Diagnosis and Treatment

Open Access Macedonian Journal of Medical Sciences, 2018
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB). Diagnosis and treatment for LTBI are important for TB, especially in high-risk populations.
Ilievska-Poposka, Biljana, Metodieva, Marija, Zakoska, Maja, Vragoterova, Cveta, Trajkov, Dejan   +4 more
openaire   +5 more sources

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration [PDF]

, 2015
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls.
A Apt, A Götz, A Zumla, AJ Wolf, AJ Wolf, Ali Alisaac, B Howie, B Howie, BN Howie, Changxin Wu, Christian G Meyer, D Lin, DA Murphy, Delphine Cuchet-Lourenço, Emma Stebbings, ER Chimusa, F Zhang, FR Zhang, Francis Drobniewski, Helen L Zenner, Ingelore Baessmann, J Marchini, James Curtis, JB Maller, JD Ernst, Jeffrey C Barrett, Jimmy Z Liu, JM Korn, JP Ehlers, JS Szeszko, Kitty Lo, L Jostins, LB Barreiro, Liliya Kopanitsa, LL Roberts, M Möller, Mailis Maes, Olga Ignatyeva, PA Randazzo, Peter Nürnberg, PL Lin, Rolf D Horstmann, S Bharti, Sergey Nejentsev, T Müller, T Thye, T Thye, Thorsten Thye, Vincent Plagnol, Vladyslav Nikolayevskyy, Y Onodera, Yang Luo, Yanina Balabanova, Z Nie   +53 more
core   +8 more sources

Spreading of Persistent Infections in Heterogeneous Populations [PDF]

, 2010
Up to now, the effects of having heterogeneous networks of contacts have been studied mostly for diseases which are not persistent in time, i.e., for diseases where the infectious period can be considered very small compared to the lifetime of an ...
D. Bleed, D. J. Daley, J. D. Murray, J. Sanz, K. Styblo, K. Styblo, L. M. Floría, R. M. Anderson, T. Daniel, Y. Moreno   +9 more
core   +2 more sources

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Transformative Pathways for Strengthening Climate‐Resilient Health Systems Among Indigenous Communities: Advancing Equity and Sustainability in Global Health

Sustainable Development, EarlyView.
ABSTRACT Most climate‐resilience health interventions are designed at the global level, with minimal attention to Indigenous communities' needs. The lack of consideration can lead to unintended harm and exacerbate health risks. This study aims to identify the capacities of Indigenous communities that can serve as transformative pathways in safely ...
Chrishma D. Perera, Eranga K. Galappaththi, Carol Zavaleta‐Cortijo, Timothy D. Baird, Korine N. Kolivras, James D. Ford, Michelle Dickson, Kerrie Pickering, Guangqing Chi, Joana Bezerra, Dhanya Vijayan, Victoria Chicamana‐Zapata, Cecil Togarepi, Kheminda G. Thilakarathne, Martha M. Hangula, Francis A. Akugre, Richard Nuwagira, Jonathan Nkalubo   +17 more
wiley   +1 more source

Study of the possibility of improving the differentiation of latent and active tuberculosis infection

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Latent TB infection (LTI)-asymptomatic nontransmissiv tuberculosis infection with hidden persistence of M.tuberculosis in host organism. The problem of detection of latent tuberculosis infection is very urgent and difficult task.
Zyifi Kadimova
doaj  

Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy. [PDF]

PLoS Neglected Tropical Diseases, 2009
Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection.
Subash Babu, Sajid Q Bhat, N Pavan Kumar, R Anuradha, Paul Kumaran, P G Gopi, C Kolappan, V Kumaraswami, Thomas B Nutman   +8 more
doaj   +1 more source

A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. [PDF]

, 2019
Background: Tuberculosis (TB) remains an urgent global public health priority, causing 1.5 million deaths worldwide in 2018. There is evidence that psychosocial factors modulate immune function; however, how this may influence TB risk or BCG vaccine ...
Boccia, D, Dowd, JB, Fletcher, H, Hayward, SE, Nellums, LB, Wurie, F   +5 more
core   +2 more sources

Genomic Investigations Unveil the Genetic Underpinnings of Environmental Adaptation in African Goat Populations

Integrative Zoology, EarlyView.
This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng, Yihua Wang, Yiyuan Zhang, Lei Gao, Lili Wu, Shuping Wang, Yiyang Gao, Wanlu Shi, Kaixin Lu, Rong Deng, Junting Li, Jing Han, Xiaohui Lu, Yujie Liu, Xiaojiao Tang, Yunxia Zhang, Guoyin Li, Li Huang, Mingsheng Yang, Xiaoyan Li   +19 more
wiley   +1 more source