Results 231 to 240 of about 876,155 (293)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi, Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z. Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva‐Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C. L. Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R. Zimmer, Joseph Masdeu, Belen Pascual, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa‐Neto, for the HEAD Study, Cristiano S Aguzzoli, Livia Amaral, Guilherme Bauer‐Negrini, Bruna Bellaver, Ann D Cohen, Alvaro de Oliveira Franco, Douglas T Leffa, Pamela C L Ferreira, Firoza Z Lussier, Marina S Medeiros, Rayan Mroué, Markley S Oliveira, Tharick A Pascoal, Guilherme Povala, Andréia Rocha, Matheus S Rodrigues, Emma Ruppert, Pampa Saha, Juli Singer, Carolina Soares, Dana L Tudorascu, Raphael L Tuma, Suzanne L Baker, Cécile Tissot, Hsin‐Yeh Tsai, Pedro Rosa‐Neto, Tevy Chan, Vladimir Fonov, Yasser Iturria‐Medina, Wan Lu Jia, Jesse Klostranec, Maxime Montembault, Nesrine Rahmouni, Jenna Stevenson, Karine Provost, Paolo Vitali, Selma Avdagic, Emerine Cummings, Brian A Gordon, Danielle Gray, Victoria Tate, Joseph C Masdeu, Belen Pascual, Hwamee Oh, Xiaoyang Hu, Val Lowe, David N Soleimani‐Meigooni, Juan Fortea, Arthur Toga, Tatiana Foroud   +83 more
wiley   +1 more source

β-Adrenergic enhancement of neuronal excitability in the lateral amygdala is developmentally gated.

J Neurophysiol, 2018
Fink AE, LeDoux JE.
europepmc   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

Integration of neuroimaging signatures of aging and Alzheimer's with fluid biomarkers

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Machine learning algorithms applied to neuroimaging may aid diagnosis and disease monitoring. This study aimed to derive neuroimaging signatures of brain aging (Spatial Pattern of Atrophy for Recognition–Brain Age [SPARE‐BA]) and Alzheimer's disease (SPARE‐AD) in a diverse sample and to examine their associations with plasma ...
Mitzi M. Gonzales, Ngoc Huynh Ho, David H. Wang, Tanweer Rashid, Sachintha R. Brandigampala, Mengjin Dong, David Martinez, Sokratis Charisis, Timothy J. Hohman, Sudha Seshadri, Christos Davatzikos, Gladys Maestre, Tiffany F. Kautz, Ashley LaRoche, Vanessa M. Young, Anna Campbell Sullivan, Kristine Yaffe, Jon B. Toledo, Alzheimer's Disease Neuroimaging InitiativeHABS‐HD Study Team, Mohamad Habes   +19 more
wiley   +1 more source

A conserved pulvinar projection to the amygdala revealed in macaque monkeys (Macaca mulatta). [PDF]

Brain Struct Funct
Baldwin MKL, Mohanty A, Cummins AC, Murray EA.   +3 more
europepmc   +1 more source

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo, Priya Rajagopalan, Lu Qian, Rufuto Rahman, Daniel Goldstein, Sophia I. Thomopoulos, David A. Bennett, Lindsay A. Farrer, Thor D. Stein, Li Shen, Heng Huang, Kwangsik Nho, Andrew J. Saykin, Christos Davatzikos, Paul M. Thompson, Julia TCW, Gyungah R. Jun   +16 more
wiley   +1 more source

Association between red blood cell count and cortical functional connectivity in type 2 diabetes mellitus patients residing at high altitude: resting-state fMRI study in the Tibetan Plateau. [PDF]

Front Endocrinol (Lausanne)
Meng J, Gao Y, Li H, Feng L, Li X, Zhou Z, Hu X, Li H, He Y, Guo Y, Luo X, He W, Wu Y, Huang X.   +13 more
europepmc   +1 more source

Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We examined how amyloid beta (Aβ) and tau accumulation affected gray matter (GM) microstructural integrity and how such alterations impacted memory. METHODS We tested voxel‐wise mediation models to examine the relationships between (1) positron emission tomography‐derived Aβ and tau accumulation and GM microstructural integrity ...
Quentin Devignes, Patrick J. Pruitt, Kenneth Petscavage, Robert A. Koeppe, Roger L. Albin, Scott J. Peltier, Annalise Rahman‐Filipiak, Bruno Giordani, Alexandru D. Iordan, Benjamin M. Hampstead   +9 more
wiley   +1 more source

Weakening of Subcortical and Strengthening of Cortical Visual Pathways Across Early Adolescence. [PDF]

Hum Brain Mapp
Sangchooli A, Rowe EG, Smith RE, Dumontheil I, Garrido MI.   +4 more
europepmc   +1 more source