Results 91 to 100 of about 219,064 (327)

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee   +6 more
wiley   +1 more source

Structure and mechanism of DNA delivery of a gene transfer agent

open access: yesNature Communications, 2020
Gene transfer agents (GTAs) are phage-like particles that mediate lateral gene exchange. Here, the authors provide the structure of the GTA of Rhodobacter capsulatus (RcGTA), which resembles a tailed phage, and describe the conformational changes ...
Pavol Bárdy   +5 more
doaj   +1 more source

Recent lateral gene transfer from Pasteurella multocida into Haemophilus influenzae [PDF]

open access: yes, 2005
only availableHaemophilus influenzae is a gram-negative bacterium that exclusively colonizes humans. Nonencapsulated strains of the bacterium are found in the upper respiratory tract of healthy humans, but can also cause the respiratory diseases otitis ...
Bratkowski, Matthew   +2 more
core  

Evolution of plant ribosome-inactivating proteins [PDF]

open access: yes, 2010
This contribution presents an updated analysis of the evolution of ribosome-inactivating proteins (RIPs) in plants. All evidence suggests that an ancestor of modern seed plants developed the RIP domain at least 300 million years ago.
Peumans, Willy J, Van Damme, Els
core   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer

open access: yesBMC Biology, 2009
Background Phylogeographic reconstruction of some bacterial populations is hindered by low diversity coupled with high levels of lateral gene transfer.
Kaul Rajinder   +26 more
doaj   +1 more source

Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. [PDF]

open access: yesPLoS Computational Biology, 2013
There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral DNA is known to integrate in the human genome, but the integration of bacterial DNA has not been described. Using publicly available sequence data from the human
David R Riley   +6 more
doaj   +1 more source

A Perl Package and an Alignment Tool for Phylogenetic Networks

open access: yes, 2007
Phylogenetic networks are a generalization of phylogenetic trees that allow for the representation of evolutionary events acting at the population level, like recombination between genes, hybridization between lineages, and lateral gene transfer.
Cardona, Gabriel   +2 more
core   +1 more source

Which phylogenetic networks are merely trees with additional arcs? [PDF]

open access: yes, 2015
A binary phylogenetic network may or may not be obtainable from a tree by the addition of directed edges (arcs) between tree arcs. Here, we establish a precise and easily tested criterion (based on `2-SAT') that efficiently determines whether or not any ...
Francis, Andrew R., Steel, Mike
core   +3 more sources

Complexity, connectivity, and duplicability as barriers to lateral gene transfer [PDF]

open access: yesGenome Biology, 2007
Abstract Background Lateral gene transfer is a major force in microbial evolution and a great source of genetic innovation in prokaryotes. Protein complexity has been claimed to be a barrier for gene transfer, due to either the inability of a new gene's encoded protein to become a subunit of an existing ...
Alon Wellner, Uri Gophna, Mor N Lurie
openaire   +3 more sources

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