Results 241 to 250 of about 2,167,307 (320)

Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats. [PDF]

Neuropharmacology
Rogers A, Castro EM, Lotfipour S, Leslie FM.   +3 more
europepmc   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Targeting MCH Neuroendocrine Circuit in Lateral Hypothalamus to Protect Against Skeletal Senescence. [PDF]

Adv Sci (Weinh)
Guo B, Zhu Y, Lu S, Chen X, Ren Z, Liu Y, Luo H, Wang C, Yang X, Zhu J.   +9 more
europepmc   +1 more source

Life‐long cardiorespiratory consequences of early life stress on estrogen actions in female rats

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Early‐life adversity increases risk for disease with sex‐specific effects on brain development. While the association between early‐life stress and neuropsychiatric disorders is well established, its impact on respiratory health is poorly documented, particularly in females.
Richard Kinkead, Stéphanie Fournier, Luana Tenorio‐Lopes, Danuzia Ambrozio‐Marques   +3 more
wiley   +1 more source

A ventral pallidum-locus coeruleus-lateral hypothalamus pathway modulates brain arousal in freely behaving and isoflurane-anesthetized male mice. [PDF]

Nat Commun
Xu XY, Xiao Y, Liu X, Huang Y, Ji Y, Ji Y, Gao Y, Liu S, Yang JJ, Cao JL, Zhou C, Xiao C.   +11 more
europepmc   +1 more source

Effect of Duloxetine on the Perioperative Anxiety Status and Stress Response Following Total Hip Arthroplasty: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 11, Page 2417-2427, November 2026.
The perioperative administration of duloxetine alleviated anxiety, reduced the stress response and postoperative walking pain, and improved the quality of functional recovery and satisfaction in patients undergoing THA. ABSTRACT Objective The impact of psychological factors on surgical stress response has garnered extensive attention.
Bohua Li, Manxue Zhang, Qianhao Li, Lijun Cai, Liyile Chen, Xiaobing Pu, Pengde Kang   +6 more
wiley   +1 more source

Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture. [PDF]

Nat Commun
Braga A, Chiacchiaretta M, Pellerin L, Kong D, Haydon PG.   +4 more
europepmc   +1 more source

Impact of Reactive Temperament on Bull Fertility in Natural Service

Reproduction in Domestic Animals, Volume 61, Issue 11, November 2026.
ABSTRACT The study aimed to evaluate the influence of temperament on semen quality and fertility in Nelore bulls. Two groups were selected based on ethological analysis, consisting of animals with either calm temperament (CA, n = 8) or reactive temperament (RE, n = 8).
Larissa de Almeida Martin, Mariana Karla Francolino da Silva, Marcelo Sant’Ana Borges, Luana Gomes Fernandes, Richardt Gama Landgraf, Fábio Morato Monteiro, André Maciel Crespilho   +6 more
wiley   +1 more source

A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch. [PDF]

Sci Adv
Guo SS, Gong Y, Zhang TT, Su XY, Su XY, Wu YJ, Yan YX, Cao Y, Song XL, Xie JC, Wu D, Jiang Q, Li Y, Zhao X, Zhu MX, Xu TL, Liu MG.   +16 more
europepmc   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source