Results 251 to 260 of about 2,167,307 (320)

Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study. [PDF]

Sci Rep
Davin A, Chabardès S, Torres-Martinez N, Piallat B.   +3 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal. [PDF]

J Neurochem
Richards BK, Ch'ng SS, Simon AB, Pang TY, Kim JH, Lawrence AJ, Perry CJ.   +6 more
europepmc   +1 more source

Comprehensive Glycomic and Proteomic Analysis of Mouse Striatum and Lateral Hypothalamus Following Repeated Exposures to Cocaine or Methamphetamine. [PDF]

Mol Cell Proteomics
Sethi MK, Maccioni R, Hogan JD, Kawamura T, Repunte-Canonigo V, Chen J, Zaia J, Sanna PP.   +7 more
europepmc   +1 more source

Chemogenetic inhibition of the lateral hypothalamus effectively reduces food intake in rats in a translational proof-of-concept study. [PDF]

Sci Rep
Kovács P, Kitka T, Bali ZK, Nagy LV, Bodó A, Kovács-Öller T, Péterfi Z, Hernádi I.   +7 more
europepmc   +1 more source

Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit. [PDF]

Biol Psychiatry Glob Open Sci
Bendrath SC, Méndez HG, Dankert AM, Lerma-Cabrera JM, Carvajal F, Dornellas APS, Lee S, Neira S, Haun H, Delpire E, Navarro M, Kash TL, Thiele TE.   +12 more
europepmc   +1 more source

Prolonged stress alters the PC1/PC2 ratio in the rat lateral hypothalamus, implicating impaired orexin maturation. [PDF]

Iran J Basic Med Sci
Salami M, Elahdadi Salmani M, Lashkarbolouki T.   +2 more
europepmc   +1 more source

Repeated cycles of binge-like ethanol consumption and abstinence alter neuropeptide mRNA in prefrontal and insular cortex, amygdala, and lateral hypothalamus of male and female C57BL/6J mice. [PDF]

Alcohol Clin Exp Res (Hoboken)
Dankert AM, Kash TL, Thiele TE.
europepmc   +1 more source

Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair. [PDF]

Transl Psychiatry
Liu D, Zheng X, Hui Y, Xu Y, Du J, Du Z, Che Y, Wu F, Yu G, Zhang J, Gong X, Guo G.   +11 more
europepmc   +1 more source

Lesion of NPY Receptor-expressing Neurons in Perifornical Lateral Hypothalamus Attenuates Glucoprivic Feeding.

Endocrinology
Choi PP, Wang Q, Brenner LA, Li AJ, Ritter RC, Appleyard SM.   +5 more
europepmc   +1 more source