Results 21 to 30 of about 2,167,307 (320)

Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

Nature Neuroscience, 2023
The sleep drive builds with time spent awake. Tossell et al. show in mice that tiredness triggers neurons in the prefrontal cortex to instruct the hypothalamus to initiate nesting and then sleep itself, ensuring that sleep occurs in a safe place.
K. Tossell, Xiao Yu, P. Giannos, Berta Anuncibay Soto, Mathieu Nollet, R. Yustos, G. Miracca, Mikal Vicente, A. Miao, B. Hsieh, Ying Ma, A. Vyssotski, Tim Constandinou, Nicholas P. Franks, W. Wisden   +14 more
semanticscholar   +1 more source

A distinct parabrachial–to–lateral hypothalamus circuit for motivational suppression of feeding by nociception

Science Advances, 2021
A specific neural circuit for resolving the motivational conflict between feeding and acute pain. The motivation to eat is not only shaped by nutrition but also competed by external stimuli including pain.
Siew Cheng Phua, Yu-Lin Tan, Alison Maun-Yeng Kok, Esra Senol, Christine Jin Hui Chiam, Chun-Yao Lee, Yan-Min Peng, A. T. Lim, H. Mohammad, Jing-Xuan Lim, Yu Fu   +10 more
semanticscholar   +1 more source

Cellular Localization of Orexin 1 Receptor in Human Hypothalamus and Morphological Analysis of Neurons Expressing the Receptor

Biomolecules, 2023
The orexin system is related to food behavior, energy balance, wakefulness and the reward system. It consists of the neuropeptides orexin A and B, and their receptors, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). OX1R has selective affinity for
Konstantina Vraka, Dimitrios Mytilinaios, Andreas P. Katsenos, Anastasios Serbis, Stavros Baloyiannis, Stefanos Bellos, Yannis V. Simos, Nikolaos P. Tzavellas, Spyridon Konitsiotis, Patra Vezyraki, Dimitrios Peschos, Konstantinos I. Tsamis   +11 more
doaj   +1 more source

Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1

NeuroImage: Clinical, 2021
Introduction: functional and structural MRI studies suggest that the orexin (hypocretin) deficiency in the dorso-lateral hypothalamus of narcoleptic patients would influence both brain metabolism and perfusion and would cause reduction in cortical grey ...
Daniela Ballotta, Francesca Talami, Fabio Pizza, Anna Elisabetta Vaudano, Francesca Benuzzi, Giuseppe Plazzi, Stefano Meletti   +6 more
doaj   +1 more source

The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation

Frontiers in Neuroscience, 2020
The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain.
M. Fakhoury, Israa Salman, Wassim Najjar, G. Merhej, N. Lawand   +4 more
semanticscholar   +1 more source

Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: A 7-Tesla functional magnetic resonance imaging study

NeuroImage, 2022
Over the past two decades, magnetic resonance imaging (MRI) studies have explored brain activation patterns during acute noxious stimuli. Whilst these human investigations have detailed changes in primarily cortical regions, they have generally not ...
Rebecca V Robertson, Lewis S Crawford, Noemi Meylakh, Paul M Macey, Vaughan G Macefield, Kevin A Keay, Luke A Henderson   +6 more
doaj   +1 more source

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats

Neuroscience Bulletin, 2014
Orexin neurons within the lateral hypothalamus play a crucial role in the promotion and maintenance of arousal. Studies have strongly suggested that orexin neurons are an important target in endogenous adenosine-regulated sleep homeostasis.
Y. Cun, Lin Tang, Jie Yan, Chao He, Yang Li, Zhian Hu, Jian-Xia Xia   +6 more
semanticscholar   +2 more sources

Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats

Journal of Neuroscience, 2020
Persistent avoidance of stress-related stimuli following acute stress exposure predicts negative outcomes such as substance abuse and traumatic stress disorders.
Marcus M. Weera, R. Shackett, Hannah M. Kramer, Jason W. Middleton, N. Gilpin   +4 more
semanticscholar   +1 more source

High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus

Molecular Metabolism, 2020
Objective Orexin (ORX) and melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus are critical regulators of energy homeostasis and are thought to differentially contribute to diet-induced obesity.
V. Linehan, Lisa Z. Fang, Matthew P. Parsons, Michiru Hirasawa   +3 more
semanticscholar   +1 more source

Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis [PDF]

Molecular Neurobiology, 2022
Abstract The lateral hypothalamus (LH) has a heterogeneous cytoarchitectonic organization that has not been elucidated in detail. In this work, we analyzed within the framework of the prosomeric model the differential expression pattern of 59 molecular markers along the ventrodorsal dimension of the medial ...
Carmen Diaz, Margaret Martinez de la Torre, John L. R. Rubenstein, Luis Puelles   +3 more
openaire   +4 more sources