Results 51 to 60 of about 72,818 (259)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A limbic circuit selectively links active escape to food suppression

eLife, 2020
Stress has pleiotropic physiologic effects, but the neural circuits linking stress to these responses are not well understood. Here, we describe a novel population of lateral septum neurons expressing neurotensin (LSNts) in mice that are selectively ...
Estefania P Azevedo, Bowen Tan, Lisa E Pomeranz, Violet Ivan, Robert Fetcho, Marc Schneeberger, Katherine R Doerig, Conor Liston, Jeffrey M Friedman, Sarah A Stern   +9 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Adolescents and alcohol: Acute sensitivities, enhanced intake, and later consequences [PDF]

Neurotoxicology and Teratology, 2014
Adolescence is an evolutionarily conserved developmental period characterized by notable maturational changes in the brain along with various age-related behavioral characteristics, including the propensity to initiate alcohol and other drug use and consume more alcohol per occasion than adults.
openaire   +2 more sources

Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril ...
De Gobbi, Juliana Irani Fratucci, De Luca Jr., Laurival Antonio, Johnson, Alan Kim, Menani, José Vanderlei   +3 more
openaire   +4 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Analisis Perancangan Dinding Penahan Tanah Untuk Seawater Intake Pembangkit Listrik Tenaga Uap

Jurnal Teknik Sipil
The handling of retaining walls in the PLTU seawater intake project is a crucial part in maintaining the stability of buildings below ground level. The retaining wall construction is selected based on the depth of excavation, soil type, the height of the
Ibadurrahman Adz Dzikro, Sarah Via Mades Aweka, Azka Syarifa Amani, Harum Kurnia Jayanti, Andika Sahadewa   +4 more
doaj   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Primary Closure With Posteriorly Based Lateral Tongue Flap Reconstruction After Transoral Videolaryngoscopic Surgery for Tonsil Cancer

Ear, Nose & Throat Journal, 2022
Introduction: Transoral surgery for head and neck cancer provides excellent oncologic outcomes while preserving speech and swallowing function. When neck dissection and resection of oropharynx are performed concomitantly, there is a risk of creating a ...
Kazunori Fujiwara MD, PhD, Satoshi Koyama MD, PhD, Takahiro Fukuhara MD, PhD, Ryohei Donishi MD, Tsuyoshi Morisaki MD, PhD, Hideyuki Kataoka MD, PhD, Hiromi Takauchi MD, PhD   +6 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source