Results 1 to 10 of about 1,796 (169)

Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases [PDF]

Nature Communications, 2023
BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis, growth and repair. They act by promoting the deposition of structural extracellular matrix proteins and by controlling the activity of matricellular proteins and TGF-β ...
Sandrine Vadon-Le Goff, Agnès Tessier, Manon Napoli, Cindy Dieryckx, Julien Bauer, Mélissa Dussoyer, Priscillia Lagoutte, Célian Peyronnel, Lucie Essayan, Svenja Kleiser, Nicole Tueni, Emmanuel Bettler, Natacha Mariano, Elisabeth Errazuriz-Cerda, Carole Fruchart Gaillard, Florence Ruggiero, Christoph Becker-Pauly, Jean-Marc Allain, Leena Bruckner-Tuderman, Alexander Nyström, Catherine Moali   +20 more
doaj   +2 more sources

Characterization of the Zebrafish Elastin a (elna^sa12235) Mutant: A New Model of Elastinopathy Leading to Heart Valve Defects [PDF]

Cells, 2023
Elastic fibers are extracellular macromolecules that provide resilience and elastic recoil to elastic tissues and organs in vertebrates. They are composed of an elastin core surrounded by a mantle of fibrillin-rich microfibrils and are essentially ...
Marie Hoareau, Naïma El Kholti, Romain Debret, Elise Lambert   +3 more
doaj   +2 more sources

Spatiotemporal fluorescence imaging of microRNA activity in 3-D models of human epidermis reveals contribution of the Notch pathway in the regulation of miR-30a in aging skin [PDF]

JID Innovations
MicroRNAs are short noncoding RNAs that play important roles in fine tuning genetic networks as genes post-transcriptional regulators. Monitoring the regulatory activity of microRNAs is technically challenging, especially in primary cells and 3 ...
Alejandro Gonzalez Torres, Fabien P. Chevalier, Ruth Aquino, Mélanie Aimard, Patrick Baril, Jérôme Lamartine   +5 more
doaj   +2 more sources

Dental pulp mesenchymal stem cells-response to fibrin hydrogel reveals ITGA2 and MMPs expression [PDF]

Heliyon
Regenerative endodontic procedures (REP) aim at reestablishing tooth vitality by replacing the irreversibly damaged dental pulp removed by the dental practitioner with a new functional one.
David Tong, Stéphanie Gobert, Alicia Reuzeau, Jean-Christophe Farges, Marianne Leveque, Marie Bolon, Arthur Costantini, Marielle Pasdeloup, Jérôme Lafont, Maxime Ducret, Mourad Bekhouche   +10 more
doaj   +2 more sources

Molecular Dynamics Studies of Poly(Lactic Acid) Nanoparticles and Their Interactions with Vitamin E and TLR Agonists Pam₁CSK₄ and Pam₃CSK₄ [PDF]

Nanomaterials, 2020
Poly(lactic acid) (PLA) nanoparticles (NPs) are widely investigated due to their bioresorbable, biocompatible and low immunogen properties. Interestingly, many recent studies show that they can be efficiently used as drug delivery systems or as adjuvants
Simon Megy, Stephanie Aguero, David Da Costa, Myriam Lamrayah, Morgane Berthet, Charlotte Primard, Bernard Verrier, Raphael Terreux   +7 more
doaj   +2 more sources

Development of thymic tumor in [LSL:Kras G12D ; Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis [PDF]

Scientific Reports, 2021
Pancreatic Ductal AdenoCarcinoma (PDAC) represents about 90% of pancreatic cancers. It is one of the most aggressive cancer, with a 5-year survival rate below 10% due to late diagnosis and poor therapeutic efficiency.
Sophie Liot, Naïma El Kholti, Jonathan Balas, Laurent Genestier, Bernard Verrier, Ulrich Valcourt, Elise Lambert   +6 more
doaj   +2 more sources

Method for Large-scale Production of hIPSC Spheroids [PDF]

Bio-Protocol
Stem cell spheroids are rapidly becoming essential tools for a diverse array of applications ranging from tissue engineering to 3D cell models and fundamental biology.
Lucas Lemarié, Edwin Courtial, Jérôme Sohier   +2 more
doaj   +2 more sources

Facilitators and barriers to latent tuberculosis infection treatment among primary healthcare workers in Malaysia: a qualitative study [PDF]

BMC Health Services Research, 2023
Background Healthcare workers (HCWs) have an increased risk of active and latent tuberculosis infection (LTBI) compared to the general population. Despite existing guidelines on the prevention and management of LTBI, little is known about why HCWs who ...
Siti Nur Farhana H., Anusha Manoharan, Wen Ming Koh, Manimaran K., Ee Ming Khoo   +4 more
doaj   +2 more sources

Influence of Aging and Diabetes on the Mechanical Properties of Mouse Skin [PDF]

Dermatopathology
Background: Diabetics accumulate Advanced Glycation End products (AGEs) such as Nε-(carboxymethyl)lysine (CML) in their skin, which can provoke changes in the skin’s biomechanical properties. The same changes are also observed during aging.
Sarah Miny, Gaël Runel, Julien Chlasta, Christelle Bonod   +3 more
doaj   +2 more sources

Interferon-gamma release assays for diagnosis of latent TB infection in chronic kidney diseases and dialysis patients [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionPatients with chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), are at risk of developing tuberculosis (TB). The prevalence and predictors of LTBI assessed by a high-sensitivity, high-specificity test such as an ...
Pattorn Hayuk, Sarinya Boongird, Prapaporn Pornsuriyasak, Jackrapong Bruminhent   +3 more
doaj   +2 more sources