Results 111 to 120 of about 21,610 (241)
Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Tristan Möller +2 more
wiley +1 more source
Psilocybin Production With Genetically Modified Aspergillus nidulans Under Pressurized Conditions
Biotechnology and Bioengineering, Volume 123, Issue 4, Page 886-898, April 2026.Shake flask cultures of psilocybin‐producing A. nidulans were investigated with respect to nitrogen source, rheology, power input, and oxygen availability, and subsequently scaled to a stirred tank reactor scale based on specific power input to develop and optimize a pressurized bioprocess.
Sophie Weiser +7 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan +13 more
wiley +1 more source
Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong +8 more
wiley +1 more source
Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.ABSTRACT The quality control of therapeutic antisense oligonucleotides (ASOs) poses significant analytical challenges due to the complexity of their synthesis and degradation processes and the need to ensure the safety and efficacy of active pharmaceutical ingredients (APIs).
Antonio Triolo +4 more
wiley +1 more source
HPLC‐Orbitrap‐MS for the Determination of B‐Vitamins in Fruit Juices and Food Supplements
Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026.ABSTRACT Accurate assay of vitamins in foods is a considerable analytical challenge due to the chemical complexity of matrices and molecular structures. Orbitrap MS technology coupled with liquid chromatography through electrospray ionization source (HPLC‐ESI‐MS) was applied for the simultaneous determination of seven B‐vitamins (thiamin, riboflavin ...
Lucia Bartella +3 more
wiley +1 more source
Mechanism of the Photodecomposition of Stable Triarylmethyl Radicals
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.Photolysis of luminescent chlorinated trityl radicals was studied with density functional theory and the decomposition products were isolated and characterized. It proceeds by a 5‐electron electrocyclization then a 1,8‐sigmatropic chloride shift, forming non‐emissive, less stable fluorenyl radicals.
Hannah E. Hackney +3 more
wiley +2 more sources
LC-HRMS-Analyse von Ceramiden und Cerebrosiden in Lonicera japonica
, 2022 Aufgrund seiner vielen gesundheitsfördernden Wirkungen kommt das japanische Geißblatt (Lonicera japonica) in der Traditionellen Chinesischen Medizin häufig zur Behandlung von Erkrankungen wie Hepatitis, rheumatischer Arthritis und Infektionskrankheiten wie COVID-19 zum Einsatz.
openaire
New Phytologist, Volume 250, Issue 2, Page 1313-1329, April 2026.Summary With current climate trajectories, tree populations will encounter novel selection pressures that risk local extinction if they are unable to acclimate or adapt. Within a reciprocal transplant experiment with Quercus macrocarpa L. established across a latitudinal gradient, we asked: (1) Is there genetic variation within populations?
Lucy M. S. Rea +8 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.The combined therapy decreased inflammatory and angiogenic signaling and altered bone marrow cell profiles linked to tumor dormancy, indicating a potential approach to limit disease progression and reduce relapse risk in breast cancer. ABSTRACT Disseminated tumor cells (DTCs) in the bone marrow can survive in a dormant state and later reawaken to drive
Hayarpi Javrushyan +7 more
wiley +1 more source