Results 221 to 230 of about 21,610 (241)

LC-HRMS analysis of 13 classes of pharmaceutical substances in food supplements

Food Additives & Contaminants: Part B, 2023
Food supplements should not contain substances considered unsafe or pose a health risk to consumers. In recent years illegal adulterants have been found in various functional foods without notification of their presence or amount in the labelling. In this study, a validated method was developed and applied as a screening method to detect 124 forbidden ...
Luigi, Giannetti, Valentina, Gallo, Francesco, Necci, Francesca, Marini, Andrea, Giorgi, Elisa, Sonego, Francesca, D'Onofrio, Bruno, Neri   +7 more
openaire   +2 more sources

Modular, Scalable, and Customizable LC-HRMS for Exposomics

In this chapter, we describe a multi-purpose, reversed-phase liquid chromatography-high-resolution mass spectrometry (LC-HRMS) workflow for acquiring high-quality, non-targeted exposomics data utilizing data-dependent acquisition (DDA) combined with the use of toxicant inclusion lists for semi-targeted analysis.
Vinicius Verri, Hernandes, Benedikt, Warth   +1 more
openaire   +2 more sources

Extraction strategies for tackling complete hair metabolome using LC-HRMS-based analysis

Talanta, 2021
Over recent years, metabolomics has been featured as the state-of-the-art technology that successfully opens the paths to understanding biological mechanisms and facilitating biomarker discovery. However, the inherent dynamic and sensitive nature of the metabolome have been challenging the accuracy of capturing the timepoints of interest while using ...
William Chih-Wei, Chang, Pin-Hsuan, Wang, Chih-Wei, Chang, Yuan-Chih, Chen, Pao-Chi, Liao   +4 more
openaire   +2 more sources

IDSL.IPA Characterizes the Organic Chemical Space in Untargeted LC/HRMS Data Sets

Journal of Proteome Research, 2022
Generating comprehensive and high-fidelity metabolomics data matrices from LC/HRMS data remains to be extremely challenging for population-scale large studies (n > 200). Here, we present a new data processing pipeline, the Intrinsic Peak Analysis (IDSL.IPA) R package (https://ipa.idsl.me), to generate such data matrices specifically for organic ...
Sadjad Fakouri Baygi, Yashwant Kumar, Dinesh Kumar Barupal   +2 more
openaire   +2 more sources

Profiling polar lipids in whey protein phospholipid concentrate by LC-HRMS/MS

Food Chemistry, 2022
Bioactive polar lipids in the milk fat globular membrane can be recovered and enriched during whey protein processing into a co-product called whey protein phospholipid concentrate (WPPC). A food-grade solvent successfully extracted polar lipids from powdered dairy products, and lipids can be fractionated under temperature-induced crystallization. This
Quintin, Ferraris, Armando, Alcazar, Michael C, Qian   +2 more
openaire   +2 more sources

A novel LC-HRMS method reveals cysteinyl and glutathionyl polysulfides in wine

Talanta, 2020
A novel ultra high pressure liquid chromatography combined with high resolution mass spectrometry (UHPLC-HRMS) method was developed to study glutathionyl and cysteinyl polysulfides in wine. Different HPLC columns were investigated in order to optimise the chromatographic resolution of the polysulfide standard mixtures synthesised in-house.
van Leeuwen, Katryna A, Nardin, Tiziana, Barker, David, Fedrizzi, Bruno, Nicolini, Giorgio, Larcher, Roberto   +5 more
openaire   +4 more sources

Comprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS

Food Research International, 2020
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkanoyl-5-hydroxytryptamides (C-5HT).
Ana Carolina R, Silva, Carol Cristine, da Silva, Rafael, Garrett, Claudia M, Rezende   +3 more
openaire   +2 more sources

Quantification of Efavirenz Hydroxymetabolites in Human Plasma Using LC-HRMS/MS

Therapeutic Drug Monitoring
Background: Efavirenz (EFV) is a drug used to treat HIV. Low plasma concentrations of EFV result in suboptimal viral suppression, whereas high concentrations can cause adverse neuropsychiatric side reactions. Some studies have identified a correlation between the plasma concentrations of EFV metabolites and neurotoxicity.
Madeleine, Pettersson Bergstrand, Sandra, Soeria-Atmadja, Victoria, Barclay, Jelena, Tolic, Lars, Navér, Lars L, Gustafsson, Anton, Pohanka   +6 more
openaire   +2 more sources

Suzetrigine in Equestrian Sports: Optimized Extraction and LC-HRMS Detection Strategies

Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Suzetrigine, a recently approved Na V 1.8 sodium channel blocker, shows strong potential in the treatment of neurological, psychiatric, and pain‐related conditions. Its peripheral selectivity enables effective
Meleparappil Muhammed Ajeebsanu, Shino Ann Koshy, Abdul Khader Karakka Kal, Michael Benedict Subhahar, Tajudheen K. Karatt, Moses Philip   +5 more
openaire   +1 more source

2D LC HRMS analysis of bivalirudin and its degradation products

2019
Bivalirudin is a direct thrombin inhibitor which is used as anticoagulant for patients with acute coronary syndromes or patients undergoing percutaneous coronary intervention [1]. It is a synthetic oligopeptide, consists of 20 amino acids (D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly- Asp- Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu), and specifically binds to ...
Vukoja, Andreja, Galović, Sanja, Galić, Nives   +2 more
openaire   +2 more sources