A Multidimensional Workflow for Comprehensive Xenometabolome Profiling by Integrating TIMS-PASEF with LC-HRMS and Biotransformation-Informed Suspect and Nontarget Screening. [PDF]
Anal ChemDamalas DE, Thomaidis NS.
europepmc +1 more source
ChemistrySelect, Volume 11, Issue 37, 6 October 2026.Natural‐light ageing of early azo dyes and hydrazone pigments (AY36, AO7, and AR1) on cellulose‐based supports produces marked chromatic changes and distinct molecular transformations. LC–HRMS analysis of aged AY36 reveals degradation products associated with N‐oxidation, N‐dearylation, azo‐bond oxidation, and formaldehyde addition, providing a first ...
Adele Ferretti +2 more
wiley +1 more source
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog +5 more
wiley +2 more sources
Smart Medicine, Volume 5, Issue 5, October 2026.AC591 and its core active component 18β‐glycyrrhetinic acid effectively alleviate cisplatin‐induced ototoxicity by binding p53 and suppressing p53‐mediated ferroptosis, representing promising agents for preventing cisplatin‐related hearing loss. ABSTRACT Cisplatin is a widely utilized chemotherapeutic agent for the treatment of malignant cancers ...
Yunhao Wu +9 more
wiley +1 more source
An Exploratory LC-HRMS Metabolomics Study of Culture Medium-Dependent Metabolic Variation and Bioactivity in Ten Fungal Strains. [PDF]
Int J Mol SciDesai R +8 more
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Untargeted LC-HRMS metabolomic analysis reveals exercise-induced biochemical alterations in endurance Arabian horses. [PDF]
BMC Vet ResMyćka G +3 more
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Assessment of Monomer Release From Resin Composites Following the Use of Various Modeling Liquids
Journal of Esthetic and Restorative Dentistry, Volume 38, Issue 10, Page 1933-1946, October 2026.ABSTRACT Objectives The chemical composition of resin composites and the use of modeling liquids may influence the release of residual monomer, potentially impacting biocompatibility. This in vitro study evaluated the effect of different modeling liquids on the elution of monomers from two resin composites.
Dorukcan Yıldırım +3 more
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Untargeted LC-HRMS of Dried Blood Spots Reveals Metabolic Alterations and Candidate Biomarkers in Glutaric Aciduria Type-1. [PDF]
MetabolitesMujamammi AH +9 more
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Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto‐Acyl Carrier Proteins
ChemBioChem, Volume 27, Issue 18, 28 September 2026.Probes were rationally designed to capture key intramolecular interactions thorugh photocrosslinking in thiotemplated assembly lines: polyketide synthases (PKS), fatty acid synthases (FAS), and non‐ribosomal peptide synthetases (NRPS). Poor or no crosslinking was observed from these probes, highlighting current limitations of synthetic and structural ...
Anna‐Kay R. West +6 more
wiley +1 more source
Carbamoylation as an Effective Tool in the Analysis of the Soman Nerve Agent Marker Pinacolyl Alcohol in Soil Matrices by EI-GC-MS and LC-HRMS. [PDF]
ACS OmegaBaliu-Rodriguez D +6 more
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