Results 191 to 200 of about 255,317 (292)

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC-HRMS/MS, Molecular Docking, and ADMET Analysis. [PDF]

Chem Biodivers
Abidi J, Hassena AB, Hmida RB, Kulinowski Ł, Aytar EC, Al-Rashidi RR, Bouaziz M.   +6 more
europepmc   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Linking Targeted GC-MS Disinfection Byproduct Analysis with Nontargeted LC-HRMS Characterization of Dissolved Organic Matter to Evaluate Drinking Water Treatment Performance. [PDF]

ACS ES T Water
Zafra-Navarro F, Martí S, Schum S, Emiliano P, Petrovič M, Farré MJ.   +5 more
europepmc   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Quantitative Method for Analysis of Lipids by LC-HRMS and Fatty Acid Methyl Ester by GC-FID in Macauba (Acrocomia aculeata) Oils. [PDF]

Plants (Basel)
Ferro EZS, Brand ALM, Teixeira RSS, Rezende CM.   +3 more
europepmc   +1 more source

Test of Bioactive Compounds from Ethanol Extract of Rantiti Leaves (Cipadessa baccifera (Roxb.Ex Roth) Miq.) Using LC-HRMS Method

Background: Rantiti (Cipadessa baccifera (Roxb.Ex Roth) Miq.), is known locally as rantiti leaves. This plant belongs to the Meliaceae family and is traditionally used to treat various health disorders.
Santika Tanjung, Annisa Della
core  

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, Volume 13, Issue 34, 19 June 2026.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Trapped Ion Mobility Improves Annotation Accuracy in LC-HRMS Screening Applications for Exposomics. [PDF]

Anal Chem
Huber C, Ulrich N, Krauss M.
europepmc   +1 more source

¹³C-labeled Mouse Urines Metabolomics by LC - HRMS : towards the identification of new biomarkers

Les métabolites sont souvent décrits comme étant le groupe de molécules le plus proche du phénotype d'un individu. Ce sont alors des cibles de choix pour étudier les dysfonctionnements d'un organisme engendrés, par exemple, par une maladie.
Legrand, Anaïs
core  

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source