Results 221 to 230 of about 330,504 (280)

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, Volume 65, Issue 38, 14 September 2026.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC-HRMS/MS, Molecular Docking, and ADMET Analysis. [PDF]

Chem Biodivers
Abidi J, Hassena AB, Hmida RB, Kulinowski Ł, Aytar EC, Al-Rashidi RR, Bouaziz M.   +6 more
europepmc   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

Organ-Resolved Salicylate-Phenylpropanoid Metabolite Profiling of <i>Echinacea purpurea</i>, <i>E. pallida</i>, and <i>E. tennesseensis</i> Tissues Extracted with 50% Aqueous Methanol by LC-MS/MS and LC-HRMS. [PDF]

Molecules
Chang C, Du M, Zhang Y, Lau T, Slama JV, O'Brien R, Ibi A, Solnier J.   +7 more
europepmc   +1 more source

Redefining Fluoroquinolone Antibiotics: Design and Synthesis of Degradable Fluoroquinolones to Reduce Environmental Persistence

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
Redesign and development of an efficient, robust synthesis platform for environmentally improved fluoroquinolones. A significant challenge associated with antibiotics, and active pharmaceutical ingredients in general, is their intentional design for high stability, which promotes environmental persistence and contributes to the development of ...
Nathan Raeymackers, Emile De Mol, Martin Yenokyan, Morten Suk, Klaus Kümmerer, Thomas S. A. Heugebaert, Christian V. Stevens   +6 more
wiley   +1 more source

ChromAnnot a webserver for deep LC-HRMS/MS chromatogram annotation

, 2023
Bertrand, Samuel, Mottu, Jean-Marie, Roullier, Catherine, Guitton, Yann   +3 more
openaire   +1 more source

Linking Targeted GC-MS Disinfection Byproduct Analysis with Nontargeted LC-HRMS Characterization of Dissolved Organic Matter to Evaluate Drinking Water Treatment Performance. [PDF]

ACS ES T Water
Zafra-Navarro F, Martí S, Schum S, Emiliano P, Petrovič M, Farré MJ.   +5 more
europepmc   +1 more source

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, Volume 36, Issue 74, 14 September 2026.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

Quantitative Method for Analysis of Lipids by LC-HRMS and Fatty Acid Methyl Ester by GC-FID in Macauba (Acrocomia aculeata) Oils. [PDF]

Plants (Basel)
Ferro EZS, Brand ALM, Teixeira RSS, Rezende CM.   +3 more
europepmc   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source