Results 31 to 40 of about 21,610 (241)

Comparison of Three Untargeted Data Processing Workflows for Evaluating LC-HRMS Metabolomics Data

Metabolites, 2020
The evaluation of liquid chromatography high-resolution mass spectrometry (LC-HRMS) raw data is a crucial step in untargeted metabolomics studies to minimize false positive findings. A variety of commercial or open source software solutions are available
Selina Hemmer, Sascha K. Manier, Svenja Fischmann, Folker Westphal, Lea Wagmann, Markus R. Meyer   +5 more
doaj   +1 more source

Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women

Metabolites, 2022
Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older ...
Pauline Bosman, Valérie Pichon, Ana Carolina Acevedo, Laëtitia Le Pottier, Jacques Olivier Pers, Hélène Chardin, Audrey Combès   +6 more
doaj   +1 more source

Towards Unbiased Evaluation of Ionization Performance in LC-HRMS Metabolomics Method Development

Metabolites, 2022
As metabolomics increasingly finds its way from basic science into applied and regulatory environments, analytical demands on nontargeted mass spectrometric detection methods continue to rise. In addition to improved chemical comprehensiveness, current developments aim at enhanced robustness and repeatability to allow long-term, inter-study, and meta ...
Carsten Jaeger, Jan Lisec
openaire   +3 more sources

LC-HRMS Biomarker Suspect Screening in Low Dose Studies

ISEE Conference Abstracts, 2018
Exposure biomarker development is a time consuming procedure, starting with identification of presumably appropriate metabolites of the xenobiotic in question.
Daniel Bury, Frederik Lessmann, Kathrin Papadopoulos, Alexandra Nehring, Tobias Weiss, Heiko Hayen, Thomas Brüning, Holger Martin Koch   +7 more
openaire   +1 more source

Harnessing the Orientation of Columnar Discotic Liquid Crystals for Narrowband Blue Emission with Enhanced Out‐Coupling Efficiency Toward Improvement of SP‐OLEDs Performance

Advanced Functional Materials, EarlyView.
Solution‐processed OLEDs containing discotic liquid‐crystalline MR‐TADF emitters are reported. Supramolecular self‐assembly induces homeotropic columnar alignment, enforcing preferential horizontal orientation of the emitter transition dipole moment in spin‐coated films, which leads to an enhancement in the device light outcoupling efficiency while ...
Joydip De, Abhishek Kumar Gupta, Džiugas Litvinas, Francisco Tenopala‐Carmona, Matthias Lehmann, Malte C. Gather, Eli Zysman‐Colman   +6 more
wiley   +1 more source

Application of high-resolution mass spectrometry profiling towards the diagnosis and acute management of maple syrup urine disease

Molecular Genetics and Metabolism Reports
The current approach for investigating patients with suspected inborn errors of metabolism (IEMs) involves traditional targeted biochemical assays such as amino/organic acid analyses.
Rafael Garrett, Sara Pickett, Melinda J. Peters, Khadija Belhassan, Adam S. Ptolemy, Roy W.A. Peake   +5 more
doaj   +1 more source

Identification and Initial Testing of Anticancer Compounds from Marine Sponge Extract Clathria sp. From Padamarang Island, Kolaka Regency [PDF]

BIO Web of Conferences
A study has been conducted on the identification and initial testing of anticancer compounds from the sponge extract of Clathria sp. from the waters of Padamarang Island, Kolaka Regency. This study aims to identify compounds and conduct toxicity tests of
Zahwa Kirana Danya, Syam Ainul Mardiah, Hasmidar, Ramadhan Muhammad Fajri, Arami Hasnia, Sari Rina Sardiana   +5 more
doaj   +1 more source

Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors

Toxins, 2020
Paralytic shellfish toxins (PSTs) are a complex class of analogs of the potent neurotoxin saxitoxin (STX). Since calibration standards are not available for many PSTs, including C-11 hydroxyl analogs called M-toxins, accurate quantitation by liquid ...
Jiangbing Qiu, Elliott J. Wright, Krista Thomas, Aifeng Li, Pearse McCarron, Daniel G. Beach   +5 more
doaj   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

In Situ Photopolymerization of Smectic B Liquid‐Crystalline Electrolytes from Mesogenic Phosphate–Diacrylate/Ionic Liquid Complexes for High‐Performance Soft Ionic Actuators

Advanced Robotics Research, EarlyView.
A flexible liquid‐crystalline electrolyte membrane via in situ photopolymerization of a phosphate‐functionalized mesogen, ionic liquid, and diacrylate monomer is developed. The resulting smectic B (SmB)‐phase structure enables 2D ion transport with high conductivity (10−4 S cm−1).
Chengyang Liu, Masafumi Yoshio
wiley   +1 more source